Document Detail

The course of epilepsy during pregnancy: a study of 78 cases.
MedLine Citation:
PMID:  3147566     Owner:  NLM     Status:  MEDLINE    
We have compared frequency and severity of epileptic seizures during pregnancy with the 9 months prior to pregnancy in 66 patients with a total of 78 pregnancies. Data on total number of seizures and major seizures are analysed separately. No statistically significant differences between frequency before and during pregnancy were found. Cases with seizures before pregnancy tended to have seizures during pregnancy, but there was no association between occurrence of seizures prior to pregnancy and increased frequency during pregnancy. There was no evidence that seizures became more severe during pregnancy. No relationship was found between type of epilepsy and change in seizure frequency during pregnancy. The data suggest that our therapeutic interventions may have influenced seizure frequency in at most a minority of cases. Serum concentrations of the anti-epileptic drugs were monitored regularly during pregnancy. Only data on patients on constant drug dosages and, therefore, presumedly with the mildest seizure disorders were analysed. In the majority of cases there was a decrease in drug levels during pregnancy. Most cases tolerated this decrease without an increase in seizure frequency. On the other hand, most cases with increased frequency also had decreased drug levels.
I O Gjerde; R E Strandjord; M Ulstein
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  78     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1989-04-05     Completed Date:  1989-04-05     Revised Date:  2006-08-16    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  198-205     Citation Subset:  IM    
Department of Neurology, Haukeland Hospital, Bergen, Norway.
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MeSH Terms
Anticonvulsants / pharmacokinetics,  therapeutic use
Brain / physiopathology
Epilepsies, Partial / physiopathology
Epilepsy / drug therapy,  physiopathology*
Evoked Potentials / drug effects
Pregnancy Complications / drug therapy,  physiopathology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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