Document Detail


The course of Graves' ophthalmopathy is not influenced by near total thyroidectomy: a case-control study.
MedLine Citation:
PMID:  10583319     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The relationship between the method of treatment of hyperthyroidism due to Graves' disease and the course of Graves' ophthalmopathy is debated. Antithyroid drug therapy is associated with no change, or even amelioration, of ophthalmopathy. Although controversial, radioiodine may be followed by progression of eye disease, preventable by glucocorticoid administration. Whether thyroidectomy affects the course of ophthalmopathy is uncertain. DESIGN: In a case control study, the course of non-severe Graves' ophthalmopathy after thyroidectomy was investigated and the results compared with those observed in patients treated with methimazole. PATIENTS: Thirty patients with Graves' hyperthyroidism and non-severe/absent ophthalmopathy were treated with near-total thyroidectomy (Group 1, Tx), after achievement of euthyroidism with methimazole. After surgery, all patients started levothyroxine replacement therapy. Sixty patients treated with methimazole, matched for age, sex, duration of hyperthyroidism, degree of ocular involvement and smoking habits, were used as controls (Group 2, MMI). MEASUREMENTS: Patients were seen every 1-2 months for 12 months for thyroid tests and ocular evaluation. RESULTS: In Group 1, ocular parameters did not change in 17 of 18 patients with pre-existing ophthalmopathy, and in 12 patients without ophthalmopathy. Eye manifestations worsened only in one (3.3%) patient with pre-existing ophthalmopathy. In Group 2, ocular parameters did not change in 58 patients (33 with, and 25 without ophthalmopathy), while new ophthalmopathy occurred in two without pre-existing eye disease. One of the 30 patients treated by surgery (3.3%) had permanent hypoparathyroidism. CONCLUSIONS: Treatment of Graves' hyperthyroidism with near-total thyroidectomy in patients with non-severe or absent pre-existing ophthalmopathy is not associated in the short term with significant effects on the course of ophthalmopathy.
Authors:
C Marcocci; G Bruno-Bossio; L Manetti; M L Tanda; P Miccoli; P Iacconi; M P Bartolomei; M Nardi; A Pinchera; L Bartalena
Related Documents :
8082149 - A study of thyroid dysfunction in nigerian psychiatric outpatients.
9292939 - Autoimmune hyperthyroidism occurring late after radioiodine treatment for volume reduct...
7776719 - Commonly asked questions about thyroid function.
9478259 - Auditory even-related brain potentials in hyperthyroidism.
7057249 - Changing annual incidence of hypothyroidism after iodine-131 therapy for hyperthyroidis...
4042519 - Pharmacokinetic properties and bioavailability of methimazole.
11793949 - Antiendomysium antibodies in brazilian patients with celiac disease and their first-deg...
21978169 - Soluble vegfr1 (svegfr1) as a novel marker of amyotrophic lateral sclerosis (als) in th...
21334459 - Cholecystokinin-cholescintigraphy in adults: consensus recommendations of an interdisci...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical endocrinology     Volume:  51     ISSN:  0300-0664     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  1999 Oct 
Date Detail:
Created Date:  2000-05-11     Completed Date:  2000-05-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  503-8     Citation Subset:  IM    
Affiliation:
Dipartimento di Endocrinologia e Metabolismo, Ortopedia e Traumatologia, Medicina del Lavoro, Pisa, Italy. c.marcocci@endoc.med.unipi.it
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Antithyroid Agents / therapeutic use
Case-Control Studies
Chi-Square Distribution
Exophthalmos / drug therapy,  physiopathology,  surgery
Female
Graves Disease / drug therapy,  physiopathology,  surgery*
Humans
Male
Methimazole / therapeutic use
Statistics, Nonparametric
Thyroidectomy*
Treatment Failure
Visual Acuity
Chemical
Reg. No./Substance:
0/Antithyroid Agents; 60-56-0/Methimazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Osteoporosis and fractures in Turner syndrome-importance of growth promoting and oestrogen therapy.
Next Document:  Sensitivity and specificity of the fine needle aspiration biopsy of the thyroid: clinical point of v...