| On coupling a lumped parameter heart model and a three-dimensional finite element aorta model. | |
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MedLine Citation:
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PMID: 19609676 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aortic flow and pressure result from the interactions between the heart and arterial system. In this work, we considered these interactions by utilizing a lumped parameter heart model as an inflow boundary condition for three-dimensional finite element simulations of aortic blood flow and vessel wall dynamics. The ventricular pressure-volume behavior of the lumped parameter heart model is approximated using a time varying elastance function scaled from a normalized elastance function. When the aortic valve is open, the coupled multidomain method is used to strongly couple the lumped parameter heart model and three-dimensional arterial models and compute ventricular volume, ventricular pressure, aortic flow, and aortic pressure. The shape of the velocity profiles of the inlet boundary and the outlet boundaries that experience retrograde flow are constrained to achieve a robust algorithm. When the aortic valve is closed, the inflow boundary condition is switched to a zero velocity Dirichlet condition. With this method, we obtain physiologically realistic aortic flow and pressure waveforms. We demonstrate this method in a patient-specific model of a normal human thoracic aorta under rest and exercise conditions and an aortic coarctation model under pre- and post-interventions. |
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Authors:
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H J Kim; I E Vignon-Clementel; C A Figueroa; J F LaDisa; K E Jansen; J A Feinstein; C A Taylor |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-07-17 |
Journal Detail:
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Title: Annals of biomedical engineering Volume: 37 ISSN: 1521-6047 ISO Abbreviation: Ann Biomed Eng Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-05 Completed Date: 2009-12-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0361512 Medline TA: Ann Biomed Eng Country: United States |
Other Details:
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Languages: eng Pagination: 2153-69 Citation Subset: IM |
Affiliation:
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Department of Mechanical Engineering, Stanford University, 18 Campus Drive, Stanford, CA 94305, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / physiology* Blood Flow Velocity / physiology* Blood Pressure / physiology* Computer Simulation Finite Element Analysis Humans Models, Cardiovascular* Stroke Volume / physiology* Vascular Capacitance / physiology Vascular Resistance / physiology Ventricular Function, Left / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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