Document Detail

A cost utility analysis of the right method for screening hemoglobin E among Thai pregnant women.
MedLine Citation:
PMID:  16496168     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Inherited hemoglobin disorders are an important problem in many developing countries including Thailand. Of the several inherited hemoglobin disorders, hemoglobin E (HbE) (beta 26, GAG-AAG, Glu-Lys) is the most common hemoglobinopathy in Thailand. Presently, screening to identify carriers of hemoglobin disorders among pregnant subjects is an interesting topic in antenatal care in Thailand. Of late, many trials have been conducted to identify the right screening methods for the detection of hemoglobin disorders among Thai pregnant women. The common screening methods include red blood cell (RBC) index determination, application of mathematical model and hemoglobin electrophoresis. METHODS: Here, the author presents an evaluation of the cost utility of those tests in medical practice in Thailand. The cost/utility of hemoglobin electrophoresis is the highest followed by RBC index determination, application of mathematical model and DCIP test. RESULTS: Here, it can be shown that the cost per accurate diagnosis for DCIP is the least expensive. CONCLUSION: It is interesting to note that DCIP also posed high sensitivity in the screening for HbE disorder. Therefore, this test is the best method for screening the population, particularly pregnant women, to identify carriers of hemoglobin disorders. It should be recommended as part of antenatal care in Thailand as well as its neighbouring countries which have a similar high rate of HbE disorder.
Viroj Wiwanitkit
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Publication Detail:
Type:  Journal Article     Date:  2006-02-22
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  274     ISSN:  0932-0067     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-21     Completed Date:  2007-05-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  88-90     Citation Subset:  IM    
Department of Laboratory Medicine, Chulalongkorn University, 10330, Bangkok, Thailand.
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MeSH Terms
Cost-Benefit Analysis
Erythrocyte Count
Hemoglobin E / analysis*,  economics
Hemoglobinopathies / diagnosis*,  economics
Mass Screening / economics*,  methods
NADH, NADPH Oxidoreductases / analysis
Pregnancy Complications, Hematologic / diagnosis*,  economics
Prenatal Diagnosis / economics*,  methods
Sensitivity and Specificity
Reg. No./Substance:
9034-61-1/Hemoglobin E; EC 1.6.-/NADH, NADPH Oxidoreductases; EC 1.6.-/NADH-dichlorophenol-indophenol oxidoreductase

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