| A cost-effectiveness evaluation of amlodipine usage in patients with coronary artery disease in Sweden. | |
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MedLine Citation:
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PMID: 11926709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this analysis was to calculate the cost-effectiveness of amlodipine therapy in patients with coronary artery disease in Sweden. It is hypothesised that treatment with amlodipine will have an impact on overall cardiovascular disease treatment costs, resulting in a positive cost-effectiveness profile. A Markov cohort simulation model was constructed to simulate event-related and procedure-related health economic outcomes of coronary artery disease populations on amlodipine versus those on placebo. Patient level data from the Prospective Evaluation of the Vascular Effects of Norvasc Trial was used to populate the model. The total number of adverse cardiovascular clinical outcomes experienced over a three-year period was lower for patient on amlodipine than for those on placebo. The rate of hospitalisation per patient due to angina, coronary artery bypass graft, percutaneous transluminal coronary angioplasty, congestive heart failure, and myocardial infarction in the placebo cohort was 64.7%, while the rate in the amlodipine cohort was 46.9%. The cost per patient was Swedish kroner (SEK)26,600 for amlodipine patients and SEK27,400 for placebo patients. The use of amlodipine resulted in improved clinical outcomes as well as a slight savings in cost over a three-year period. |
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Authors:
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J J Doyle; A McGuire; R Arocho; S Arikian; J Casciano; P Svangren; R Casciano; R Kim; H Kugel |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of clinical practice Volume: 56 ISSN: 1368-5031 ISO Abbreviation: Int. J. Clin. Pract. Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-04-02 Completed Date: 2002-04-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9712381 Medline TA: Int J Clin Pract Country: England |
Other Details:
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Languages: eng Pagination: 76-81 Citation Subset: IM |
Affiliation:
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The Analytica Group, New York, NY 10016, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amlodipine
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economics*,
therapeutic use Analysis of Variance Calcium Channel Blockers / economics*, therapeutic use Cohort Studies Coronary Artery Disease / drug therapy, economics* Cost-Benefit Analysis Humans Markov Chains Models, Econometric Prospective Studies Sensitivity and Specificity Sweden |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 88150-42-9/Amlodipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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