Document Detail

The correlation of near-infrared spectroscopy with changes in oxygen delivery in a controlled model of altered perfusion.
MedLine Citation:
PMID:  17983072     Owner:  NLM     Status:  MEDLINE    
Alterations in regional tissue perfusion may precede global indications of shock. This study compared regional tissue oxygenation saturation (StO2) using near-infrared spectroscopy with standard hemodynamic and biochemical variables in 40 patients undergoing cardiopulmonary bypass (CPB). Mean arterial pressure, cardiac output, oxygen delivery, arterial blood gases, and lactate were recorded at specific intervals during surgery. Data were organized by stage of procedure, and the relationship of StO2 to established parameters was investigated. With initiation of CPB, StO2 declined by 12.9 per cent (standard deviation +/- 14.75%) with a delayed increase in lactate from 0.9 (interquartile range [IQR], 0.6-1.5) mmol/L to 2.3 (IQR, 1.8-2.5) mmol/L. The minimum StO2 value preceded the maximum lactate level by an average time of 93.9 (standard deviation +/- 86.3) minutes. Additionally, a decrease in StO2 corresponded with an increase in base deficit of 4.84 (standard deviation +/- 2.37) mEq/L over the same period. Calculated oxygen delivery decreased from a baseline value of 754 (IQR, 560-950) mL/min to 472 (IQR, 396-600) mL/min with initiation and maintenance of CPB. For patients undergoing CPB, StO2 is a reliable, noninvasive monitor of perfusion, which correlates well with oxygen delivery and identifies perfusion deficits earlier than lactate or base deficit.
Brant Putnam; Scott Bricker; Peter Fedorka; Juliette Zelada; Saad Shebrain; Bassam Omari; Frederic Bongard
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American surgeon     Volume:  73     ISSN:  0003-1348     ISO Abbreviation:  Am Surg     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-11-06     Completed Date:  2007-11-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370522     Medline TA:  Am Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1017-22     Citation Subset:  IM    
Department of Surgery, Los Angeles Biomedical Research Institute, Los Angeles County Harbor-UCLA Medical Center, Torrance, California 90509, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cardiac Output
Cardiopulmonary Bypass*
Microcirculation / physiology
Middle Aged
Monitoring, Physiologic / methods*
Oxygen / analysis*
Oxygen Consumption
Prospective Studies
Spectroscopy, Near-Infrared*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Liver transplantation for HELLP syndrome.
Next Document:  Computed tomographic brain density measurement as a predictor of elevated intracranial pressure in b...