| The correlation between striatal dopamine D2/D3 receptor availability and verbal intelligence quotient in healthy volunteers. | |
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MedLine Citation:
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PMID: 16359604 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although a correlation between the central dopaminergic system and intelligence may exist, the results from imaging studies remain inconclusive. The aim of this study was to explore the relationship between striatal dopamine D2/D3 receptor availability and verbal intelligence quotient (VIQ) using single photon emission computed tomography (SPECT). METHOD: Striatal D2/D3 receptor availability of 64 healthy subjects was determined with the [123I]iodobenzamide ([123I]IBZM) ligand. Intelligence quotients (IQs) of the subjects were measured by the Wechsler Adult Intelligence Scale--Revised (WAIS-R). RESULTS: In addition to age, left striatal D2/D3 receptor availability correlated positively with VIQ. In females, left striatal D2/D3 receptor availability was the only variable that correlated significantly with the similarities subtest of VIQ. CONCLUSIONS: There is a relationship between left striatal D2/D3 receptor availability and verbal intelligence, which varies, predominantly in males. |
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Authors:
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Jin Fu Guo; Yen Kuang Yang; Nan Tsing Chiu; Tzung Lieh Yeh; Po See Chen; I Hui Lee; Ching Lin Chu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-12-19 |
Journal Detail:
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Title: Psychological medicine Volume: 36 ISSN: 0033-2917 ISO Abbreviation: Psychol Med Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-03-15 Completed Date: 2006-08-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254142 Medline TA: Psychol Med Country: England |
Other Details:
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Languages: eng Pagination: 547-54 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain / blood supply* Cerebrovascular Circulation / physiology Corpus Striatum / metabolism* Female Health Status* Humans Intelligence* Male Receptors, Dopamine D2 / metabolism* Receptors, Dopamine D3 / metabolism* Tomography, Emission-Computed, Single-Photon Verbal Behavior* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Dopamine D2; 0/Receptors, Dopamine D3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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