Document Detail

A correlation between severe haemolytic disease of the fetus and newborn and maternal ABO blood group.
MedLine Citation:
PMID:  24975587     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To analyse anti-D quantification levels and frequency of intrauterine transfusion (IUT), per maternal ABO blood group.
BACKGROUND: Maternally derived red cell allo-antibodies can target fetal red cell antigens in utero leading to haemolytic disease and fetal anaemia. When a clinically significant allo-antibody is formed the priority is ascertaining the risk to the fetus and maternal ABO blood groups are not considered relevant.
MATERIALS AND METHODS: This was a 10-year retrospective, observational study carried out on women referred for anti-D quantification (n = 1106), and women whose fetuses required an IUT to treat fetal anaemia (n = 62) due to anti-D, in the Republic of Ireland.
RESULTS: Relative to the overall incidence of RhD allo-immunisation by blood group, women of blood group A were more likely to require IUT compared with those who were blood group O (P = 0·002).
CONCLUSION: It is known that ABO feto-maternal compatibility can influence the incidence and level of red cell allo-antibodies in pregnancy; however, it does not account for the significantly high rate of severe haemolytic disease requiring IUT seen in blood group A women.
B Doyle; J Quigley; M Lambert; J Crumlish; C Walsh; P McParland; M Culliton; K Murphy; J Fitzgerald
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-28
Journal Detail:
Title:  Transfusion medicine (Oxford, England)     Volume:  -     ISSN:  1365-3148     ISO Abbreviation:  Transfus Med     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301182     Medline TA:  Transfus Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2014 The Authors. Transfusion Medicine © 2014 British Blood Transfusion Society.
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