| The correlation between renal function and systolic or diastolic blood pressure in severe preeclamptic women. | |
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MedLine Citation:
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PMID: 16263597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the correlation between renal function and systolic or diastolic blood pressure in preeclamptic mothers. METHODS: In this prospective study from August 1998 to September 2002, 28 women >or= 28 weeks gestation with severe preeclampsia were selected. Meanwhile, 56 normotensive pregnant women without proteinuria or edema served as the control group. Urine was collected for 24 hours for all subjects. The concentration of uric acid, blood urea nitrogen, creatinine, sodium, calcium, and albumin in the 24-hour urine and blood of both groups were examined. Neonatal outcome also was evaluated. RESULTS:The serum and 24-hour urine concentration of blood urea nitrogen, creatinine, and albumin were significantly higher in severe preeclamptic women. Serum uric acid and urinary albumin/creatinine ratio was significantly higher in severe preeclamptic women compared with that in normotensive mothers and showed positive correlation with systolic or diastolic blood pressure. On the other hand, serum calcium/creatinine ratio was significantly lower in the severe preeclamptic group and negatively correlated to blood pressure. In multiple regressions, systolic or diastolic blood pressure was dependent on serum uric acid, albumin/creatinine, and calcium/creatinine ratios. Fetal birth weight was significantly lower in women with severe preeclampsia and with a lower Apgar score < 7 at 1 minute and 5 minutes and more preterm delivery compared with that in normotensive women. CONCLUSION: Renal function in women with severe preeclampsia was significantly impaired and highly correlated with systolic or diastolic blood pressure. |
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Authors:
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Kok-Min Seow; Ming-Hwa Tang; Jesse Chuang; Yuan-Yung Wang; Da-Chung Chen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy Volume: 24 ISSN: 1064-1955 ISO Abbreviation: Hypertens Pregnancy Publication Date: 2005 |
Date Detail:
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Created Date: 2005-11-02 Completed Date: 2006-05-04 Revised Date: 2009-05-12 |
Medline Journal Info:
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Nlm Unique ID: 9421297 Medline TA: Hypertens Pregnancy Country: United States |
Other Details:
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Languages: eng Pagination: 247-57 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan. m0022492249@yahoo.com.tw |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Urea Nitrogen Calcium / metabolism Chi-Square Distribution Creatinine / metabolism Diastole Female Humans Kidney Diseases / blood*, urine* Pre-Eclampsia / blood*, urine* Pregnancy Pregnancy Outcome Prospective Studies Regression Analysis Serum Albumin / metabolism Sodium / metabolism Systole Uric Acid / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Serum Albumin; 60-27-5/Creatinine; 69-93-2/Uric Acid; 7440-23-5/Sodium; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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