| The correlation between motor impairment and cerebral blood flow in Sturge-Weber syndrome. | |
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MedLine Citation:
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PMID: 17317246 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent studies of regional cerebral blood flow (rCBF) and cerebral metabolism in patients with Sturge-Weber syndrome (SWS) have demonstrated a regional decrease of CBF and metabolism in the affected hemisphere, which may reflect the neurological status of the patients. Therefore, in the present study, we use stable xenon computed tomography (xenon-CT) and/or (99m)technetium hexamethylprophylene amine oxime ((99mTc)HMPAO) single photon emission computed tomography (SPECT) to determine whether the degree of cerebral hemodynamic disturbance correlates with the severity of motor impairment in 5 children with Sturge-Weber syndrome. We found that 5 patients had great variation in clinical progression and outcome, but MR imaging investigations all revealed extensive but stable abnormalities. rCBF, assessed by stable xenon-CT and/or (99mTc)HMPAO-SPECT, showed perfusion defect in all subjects. However, the xenon-CT disclosed reduction of rCBF and cerebrovascular reactivity in patients with severe motor paralysis. The total CBF and rCBF detected by xenon-CT were improved after clinical status was stabilized. We conclude that the motor function impairment in patients with SWS appeared to better correlate with the degree of rCBF impairment than with the abnormalities in conventional neuroimaging. Therefore, the quantitative CBF study is one of the diagnostic modality of choice in evaluating the neurological status in patients with SWS. |
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Authors:
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Tsui-Wen Yu; Hon-Man Liu; Wang-Tso Lee |
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Publication Detail:
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Type: Journal Article Date: 2007-02-20 |
Journal Detail:
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Title: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society Volume: 11 ISSN: 1090-3798 ISO Abbreviation: Eur. J. Paediatr. Neurol. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-05 Completed Date: 2007-06-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9715169 Medline TA: Eur J Paediatr Neurol Country: England |
Other Details:
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Languages: eng Pagination: 96-103 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Circulation Time Brain Mapping Cerebrovascular Circulation / physiology* Child Child, Preschool Electroencephalography Female Humans Magnetic Resonance Imaging / methods Male Movement Disorders / etiology*, radionuclide imaging Organotechnetium Compounds Regional Blood Flow Statistics as Topic* Sturge-Weber Syndrome / physiopathology*, radionuclide imaging Tomography, Emission-Computed, Single-Photon / methods |
| Chemical | |
Reg. No./Substance:
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0/Organotechnetium Compounds |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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