Document Detail

The correlation between heart period variability and mean period length.
MedLine Citation:
PMID:  1557568     Owner:  NLM     Status:  MEDLINE    
Heart rate variability and heart period variability are important indicators of the functioning of the autonomic nervous system and are strong predictors of survival after myocardial infarction. The standard deviation of a patient's series of normal heart periods (consecutive normal RR intervals) is positively and, in some populations, strongly correlated with the mean period length. This phenomenon has led some investigators to use the coefficient of variation as their measure of variability, because it correlates less strongly with the mean period length. Using data from a multicentre post-infarction natural history study, we show that the standard deviation of the instantaneous heart rates has, like the coefficient of variation, only a modest correlation with the mean period length. Unlike the coefficient of variation, however, this standard deviation is derivable from established statistical principles. We show further that the coefficient of variation, the standard deviation of heart rates, and the standard deviation of heart periods are approximately equally strong predictors of survival after myocardial infarction.
J L Fleiss; J T Bigger; L M Rolnitzky
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Statistics in medicine     Volume:  11     ISSN:  0277-6715     ISO Abbreviation:  Stat Med     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-05-04     Completed Date:  1992-05-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8215016     Medline TA:  Stat Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  125-9     Citation Subset:  IM    
Division of Biostatistics, Columbia University School of Public Health, New York, NY 10032.
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MeSH Terms
Autonomic Nervous System / physiopathology
Electrocardiography, Ambulatory / statistics & numerical data*
Heart Rate / physiology*
Myocardial Infarction / mortality*,  physiopathology
Proportional Hazards Models
Survival Rate
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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