| The correlation between C-reactive protein and toxic granulation of neutrophils in the peripheral blood. | |
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MedLine Citation:
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PMID: 20822591 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: During inflammation, the serum concentrations of granulocyte colony stimulating factor (G-CSF), plasma interleukin-6 (IL-6), and C-reactive protein (CRP) increase. A positive correlation between CRP and the percentages of neutrophils exhibiting toxic granulation during inflammation has been demonstrated, and that the fluctuations of CRP and toxic granulation of neutrophils were similar. OBJECTIVES: We studied whether grading of toxic granulated neutrophils can be used as a surrogate marker for infection or inflammation, and also be an easier method than previously described methods. MATERIALS AND METHODS: We graded 357 consecutive peripheral blood slides from patients on whom a full blood count with differential count and CRP level was performed, according to intensity of toxic granulation in the neutrophil population, according to a newly proposed grading system. RESULTS: The CRP range was between 1 and 530.3 mg/l. The results confirm the association between a rise in CRP and progressive intensity of toxic granulation in neutrophils in peripheral blood. Kruskal-Wallis equality of populations rank test showed a statistically significant difference between the graded categories (p=0.0001). The Trend test was also statistically significant (p=0.000). CONCLUSION: The proposed system can be applied to patients with inflammatory or infectious conditions, where grading of toxic granulation of neutrophils can possibly be used as a surrogate marker to assess infection or inflammation and their response to treatment. It may be of particular use in cases where traditional infectious or inflammatory markers cannot be used, owing to inherent problems associated with the respective conditions. |
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Authors:
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A van de Vyver; E F Delport; M Esterhuizen; R Pool |
Publication Detail:
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Type: Journal Article Date: 2010-07-05 |
Journal Detail:
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Title: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde Volume: 100 ISSN: 0256-9574 ISO Abbreviation: S. Afr. Med. J. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-09-08 Completed Date: 2010-09-28 Revised Date: 2010-10-12 |
Medline Journal Info:
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Nlm Unique ID: 0404520 Medline TA: S Afr Med J Country: South Africa |
Other Details:
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Languages: eng Pagination: 442-4 Citation Subset: IM |
Affiliation:
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Department of Haematology, University of Pretoria. annievdvyver@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood C-Reactive Protein / analysis* Humans Infection / blood Inflammation / blood Leukocyte Count Neutrophils / pathology* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
Comment In:
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S Afr Med J. 2010 Sep;100(9):546; author reply 546
[PMID:
20822632
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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