| A correlation analysis of the regional distribution of central enkephalin and beta-endorphin immunoreactive terminals and of opiate receptors in adult and old male rats. Evidence for the existence of two main types of communication in the central nervous system: the volume transmission and the wiring transmission. | |
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MedLine Citation:
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PMID: 3022556 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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By means of semiquantitative immunocytochemistry and quantitative receptor autoradiography a correlation analysis has been performed on the pre- and post-synaptic features of enkephalin and beta-endorphin immunoreactive neuron systems of the 3- and 24-month-old male rat. A parallel disappearance of enkephalin- and beta-endorphin-like immunoreactivity and of the density of mu and delta opiate receptors is shown during ageing. Furthermore, the lack of an overall correlation between the amount of pre- and post-synaptic components of the enkephalin and beta-endorphin synapses give evidence for the existence of a volume type of transmission in such systems in the telencephalic, diencephalic and mesencephalic areas analysed. |
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Authors:
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L F Agnati; K Fuxe; M Zoli; I Ozini; G Toffano; F Ferraguti |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Acta physiologica Scandinavica Volume: 128 ISSN: 0001-6772 ISO Abbreviation: Acta Physiol. Scand. Publication Date: 1986 Oct |
Date Detail:
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Created Date: 1986-12-05 Completed Date: 1986-12-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370362 Medline TA: Acta Physiol Scand Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 201-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Autoradiography Brain / physiology* Endorphins / metabolism* Enkephalins / metabolism* Fluorescent Antibody Technique Male Nerve Endings / metabolism* Neurons / metabolism Rats Rats, Inbred Strains Receptors, Opioid / metabolism* Synaptic Transmission* beta-Endorphin |
| Grant Support | |
ID/Acronym/Agency:
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MH 25504/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Endorphins; 0/Enkephalins; 0/Receptors, Opioid; 60617-12-1/beta-Endorphin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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