| The correlation among QTc interval, hyperglycaemia and the impaired autonomic activity. | |
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MedLine Citation:
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PMID: 19963442 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The QT interval reflects the duration of the intracellular action potential. Little is known on the interval QT duration in non diabetic insulin-resistant subjects. OBJECTIVE: The aims of the current study were to evaluate the QTc interval in three groups of non diabetic insulin-resistant subjects and the possible correlation between QTc and the autonomic nervous system's activity. DESIGN: 90 subjects were divided in subjects with impaired fasting glycaemia (IFG) and, by the results of OGTT, according to the criteria of ADA, in subjects with normal glucose regulation (NGR) and impaired glucose tolerance (IGT). Insulin resistance was evaluated by the homeostasis model assessment-index (HOMA-I). Heart rate variability and Qtc were calculated. RESULTS: QTc interval is correlated with SDNN, LF n.u. and LF/HF. CONCLUSION: We have observed that the QTc interval is prolonged in insulin-resistant subjects with associated impaired glucose metabolism, while no difference was reported between insulin-resistant and non insulin-resistant subjects with normal glucose regulation. We hypothesize that hyperglycaemia could play a major role than hyperinsulinemia on the QTc prolongation. |
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Authors:
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Alessandra Fiorentini; Antonio Perciaccante; Rosita Valente; Alberto Paris; Pietro Serra; Luigi Tubani |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2009-12-05 |
Journal Detail:
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Title: Autonomic neuroscience : basic & clinical Volume: 154 ISSN: 1872-7484 ISO Abbreviation: Auton Neurosci Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-24 Completed Date: 2010-06-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100909359 Medline TA: Auton Neurosci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 94-8 Citation Subset: IM |
Copyright Information:
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2009 Elsevier B.V. All rights reserved. |
Affiliation:
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UO Geriatria, Hospital of Montefiascone POC, Viterbo, Italy. fiorentini-a@libero.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Autonomic Nervous System Diseases / complications* Blood Glucose / physiology Blood Pressure / physiology Electrocardiography Female Functional Laterality Glucose Tolerance Test / methods Heart Rate / physiology* Humans Hyperglycemia / complications* Insulin Resistance / physiology Long QT Syndrome / etiology* Male Middle Aged Retrospective Studies Statistics as Topic* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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