| The coronary vasculature and the myocardium. | |
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MedLine Citation:
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PMID: 11148981 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of bradykinin (BK) on myocardial inotropic state was tested on 5 isolated rat heart preparations, in which a proper ballon was placed to record left ventricular pressure, whose developed systolic value was taken as an index of contractility. A reduction of developed left ventricular pressure was observed when BK was added to the perfusion oxygenated Tyrode solution. However, when BK was given after 1-amino-benzotriazole, an inhibitor of Cytochrome P-450 (Cyt P-450), developed pressure did not change. Since Cyt P-450 is known to act on arachidonic acid inducing the production of epoxiecocistrienoic acids (EETs) which hyperpolarizes myocardial fibres, it was argued that the reduction in contractility by bradykinin was the result of the hyperpolarizing effect of EETs. The fact that the concentration of Cyt P-450 is higher in the vascular endothelial cells than in the sarcolemma of the myocytes and the observation that the coronary resistance decreases together with the contractility suggest that the endothelium plays a pivotal role in mediating the negative inotropic effect of BK. |
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Authors:
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F Ceresa; A Delfino; A De Matteis; N Ferrero; M Novarino; A Rittà |
Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Bollettino della Società italiana di biologia sperimentale Volume: 75 ISSN: 0037-8771 ISO Abbreviation: Boll. Soc. Ital. Biol. Sper. Publication Date: 1999 Jan-Feb |
Date Detail:
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Created Date: 2001-01-08 Completed Date: 2001-01-25 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7506962 Medline TA: Boll Soc Ital Biol Sper Country: Italy |
Other Details:
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Languages: eng Pagination: 1-8 Citation Subset: IM |
Affiliation:
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Dipartimento di Neuroscienze, Sezione di Fisiologia, Università di Torino. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bradykinin / pharmacology Coronary Vessels / drug effects, enzymology, physiology* Cytochrome P-450 Enzyme System / antagonists & inhibitors, metabolism Endothelium, Vascular / drug effects, physiology Enzyme Activation / drug effects Enzyme Inhibitors / pharmacology Heart Ventricles / drug effects Myocardial Contraction / drug effects, physiology* Perfusion Rats Rats, Wistar Triazoles / pharmacology Vasodilation / drug effects, physiology* Ventricular Function* Ventricular Function, Left / drug effects, physiology Ventricular Pressure / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Triazoles; 1614-12-6/1-aminobenzotriazole; 58-82-2/Bradykinin; 9035-51-2/Cytochrome P-450 Enzyme System |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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