Document Detail

The coronary bed and its role in the cardiovascular system: a review and an introductory single-branch model.
MedLine Citation:
PMID:  1564919     Owner:  NLM     Status:  MEDLINE    
To investigate cardiovascular haemodynamics under normal and pathological conditions, a closed-loop model of the cardiovascular system already presented in the literature, has been complemented by a model of the coronary bed. Oxygen available to the myocardium is strictly related to the coronary blood flow; we have developed threshold criteria which correlate cardiac output with the coronary flow. The system utilizes control systems related to the cardiac contractility and frequency, and imitates feedback mechanisms peculiar to the heart. The work exemplifies the autoregulation of events that occur when the equilibrium of the system is disturbed. It is suggested that the heart plays an active role in trying to restore the haemodynamic parameters to their physiological values.
S Mantero; R Pietrabissa; R Fumero
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biomedical engineering     Volume:  14     ISSN:  0141-5425     ISO Abbreviation:  J Biomed Eng     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-05-21     Completed Date:  1992-05-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906074     Medline TA:  J Biomed Eng     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  109-16     Citation Subset:  IM    
Dipartimento di Bioingegneria, Politecnico di Milano, Italy.
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MeSH Terms
Blood Flow Velocity
Coronary Circulation*
Coronary Vessels*
Evaluation Studies as Topic
Heart Rate
Models, Cardiovascular*
Myocardial Contraction

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