Document Detail


The coronary arterioles in newborns, infants and children. A morphometric study of normal hearts and hearts with aortic atresia and complete transposition.
MedLine Citation:
PMID:  3943928     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The state of development of the intramyocardial coronary arterioles in normal hearts and hearts with congenital malformations is unknown, although these vessels play an important role in regulating myocardial blood flow. To remedy the situation, we studied 64 normal hearts (ranging in age from 23 weeks gestational age to 75 years), 13 hearts with complete transposition (5 with intact ventricular septum and 8 with a defect) and 11 hearts with classical aortic atresia. The medial thickness of arterioles with an external diameter from 20 to 100 microns was measured. The number of arterioles was calculated per mm2; a distinction was made between vessels between 20 and 100 microns and those smaller than 20 microns. The results show that the arteriolar vascular bed is not yet full grown at term. Within the first year of life the medial smooth muscle mass increases, most likely due to growth and peripheral extension onto the smaller branches. In the hearts of patients with aortic atresia who lived for a week or less, the arteriolar media appeared to lag behind that in normal hearts. In those patients who survived into the second post-natal week, however, the arteriolar bed was almost as anticipated for normal. The normal values obtained in the latter group could be due to intrinsic differences, rather than expressing actual and rapid growth.
Authors:
S Kurosawa; H Kurosawa; A E Becker
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cardiology     Volume:  10     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1986 Jan 
Date Detail:
Created Date:  1986-03-18     Completed Date:  1986-03-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  43-56     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aged
Arteries / growth & development*
Arterioles / growth & development*,  ultrastructure
Child
Child, Preschool
Coronary Vessels / growth & development*,  ultrastructure
Female
Heart Septal Defects, Atrial / pathology
Heart Ventricles / pathology
Humans
Infant
Infant, Newborn*
Male
Microcirculation / growth & development,  physiology
Microscopy
Middle Aged
Myocardium / pathology,  ultrastructure*
Transposition of Great Vessels / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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