Document Detail


A cornerstone in the history of hypertension: the seventieth anniversary of the discovery of angiotensin.
MedLine Citation:
PMID:  19956076     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In 1939, two independent teams, in Buenos Aires and Indianapolis, identified the polypeptide angiotensin. In 1934, Goldblatt et al. demonstrated that partial occlusion of the renal arteries produces hypertension in dogs, and Houssay in 1936 predicted the presence of a humoral mechanism and, with Fasciolo, demonstrated that the ischemic kidneys released a pressor substance that increased the recipient's blood pressure. Later on, Taquini proved that the rise in blood pressure that follows the re-establishment of circulation in kidneys was also produced by a plasmatic substance from the venous blood of acute ischemic kidneys and it was called 'hypertensin'. Then, they proved that it was the result of an enzymatic reaction in which renin was the enzyme and plasma the substrate. At the same time, in 1939, Page et al. postulated that renin activated by plasma becomes vasoactive and the substance was called 'angiotonin'. Page's group began in 1937, with the purification of renin, studying its renal hemodynamic effects. Later on, Page et al. acknowledged in 1943 the enzymatic nature of the system and renamed their so-called renin-activator as renin substrate. Both groups fused the two original names into 'angiotensin' during a meeting at Michigan in 1958, making the 'adventure of the discovery of angiotensin' a reality.
Authors:
Jos? Milei
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Publication Detail:
Type:  Historical Article; Journal Article    
Journal Detail:
Title:  Journal of cardiovascular medicine (Hagerstown, Md.)     Volume:  11     ISSN:  1558-2035     ISO Abbreviation:  J Cardiovasc Med (Hagerstown)     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-10     Completed Date:  2010-06-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101259752     Medline TA:  J Cardiovasc Med (Hagerstown)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  260-4     Citation Subset:  IM    
Affiliation:
Instituto de Investigaciones Cardiol?gicas Prof. Dr Alberto C. Taquini, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Cient?ficas y T?cnicas, Buenos Aires, Argentina. ininca@fmed.uba.ar
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MeSH Terms
Descriptor/Qualifier:
Angiotensins / history*
Animals
Argentina
History, 20th Century
Humans
Hypertension / history*
Terminology as Topic
United States
Chemical
Reg. No./Substance:
0/Angiotensins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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