Document Detail

A core metabolic enzyme mediates resistance to phosphine gas.
MedLine Citation:
PMID:  23139334     Owner:  NLM     Status:  In-Process    
Phosphine is a small redox-active gas that is used to protect global grain reserves, which are threatened by the emergence of phosphine resistance in pest insects. We find that polymorphisms responsible for genetic resistance cluster around the redox-active catalytic disulfide or the dimerization interface of dihydrolipoamide dehydrogenase (DLD) in insects (Rhyzopertha dominica and Tribolium castaneum) and nematodes (Caenorhabditis elegans). DLD is a core metabolic enzyme representing a new class of resistance factor for a redox-active metabolic toxin. It participates in four key steps of core metabolism, and metabolite profiles indicate that phosphine exposure in mutant and wild-type animals affects these steps differently. Mutation of DLD in C. elegans increases arsenite sensitivity. This specific vulnerability may be exploited to control phosphine-resistant insects and safeguard food security.
David I Schlipalius; Nicholas Valmas; Andrew G Tuck; Rajeswaran Jagadeesan; Li Ma; Ramandeep Kaur; Anita Goldinger; Cameron Anderson; Jujiao Kuang; Steven Zuryn; Yosep S Mau; Qiang Cheng; Patrick J Collins; Manoj K Nayak; Horst Joachim Schirra; Massimo A Hilliard; Paul R Ebert
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  338     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  807-10     Citation Subset:  IM    
Agri-Science Queensland, Department of Agriculture, Fisheries and Forestry, Ecosciences Precinct, Brisbane, QLD 4001, Australia.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/JX434596;  JX434597;  JX434598;  JX434599;  JX434600;  JX434601;  JX434602;  JX434603;  JX434604;  JX434605;  JX434606;  JX434607;  JX434608
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