| A core metabolic enzyme mediates resistance to phosphine gas. | |
| | |
MedLine Citation:
|
PMID: 23139334 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Phosphine is a small redox-active gas that is used to protect global grain reserves, which are threatened by the emergence of phosphine resistance in pest insects. We find that polymorphisms responsible for genetic resistance cluster around the redox-active catalytic disulfide or the dimerization interface of dihydrolipoamide dehydrogenase (DLD) in insects (Rhyzopertha dominica and Tribolium castaneum) and nematodes (Caenorhabditis elegans). DLD is a core metabolic enzyme representing a new class of resistance factor for a redox-active metabolic toxin. It participates in four key steps of core metabolism, and metabolite profiles indicate that phosphine exposure in mutant and wild-type animals affects these steps differently. Mutation of DLD in C. elegans increases arsenite sensitivity. This specific vulnerability may be exploited to control phosphine-resistant insects and safeguard food security. |
| | |
Authors:
|
David I Schlipalius; Nicholas Valmas; Andrew G Tuck; Rajeswaran Jagadeesan; Li Ma; Ramandeep Kaur; Anita Goldinger; Cameron Anderson; Jujiao Kuang; Steven Zuryn; Yosep S Mau; Qiang Cheng; Patrick J Collins; Manoj K Nayak; Horst Joachim Schirra; Massimo A Hilliard; Paul R Ebert |
Related Documents
:
|
23531824 - Environmental salinity modulates the effects of elevated co2 levels on juvenile hard sh... 20105154 - Temperature, metabolic power and the evolution of endothermy. 2633984 - Effects of methyl [5 [[4-(2-pyridinyl)-1-piperazinyl]carbonyl]-1h-benzimidazol-2-yl] ca... 21501694 - Metabolic responses in two species of crayfish (parastacus defossus and parastacus bras... 5548564 - Carrageenan-induced ulceration of the large intestine in the guinea pig. 12756284 - Shaken and stirred: muscle structure and metabolism. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Science (New York, N.Y.) Volume: 338 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-11-09 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
|
Languages: eng Pagination: 807-10 Citation Subset: IM |
Affiliation:
|
Agri-Science Queensland, Department of Agriculture, Fisheries and Forestry, Ecosciences Precinct, Brisbane, QLD 4001, Australia. |
| Data Bank Information | |
Bank Name/Acc. No.:
|
GENBANK/JX434596; JX434597; JX434598; JX434599; JX434600; JX434601; JX434602; JX434603; JX434604; JX434605; JX434606; JX434607; JX434608 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Grant Support | |
ID/Acronym/Agency:
|
R01NS060129/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Corals chemically cue mutualistic fishes to remove competing seaweeds.
Next Document: Optical control of protein activity by fluorescent protein domains.