Document Detail

Placental/umbilical cord blood: experience of st. Eugenio Hospital collection center.
MedLine Citation:
PMID:  16182780     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Umbilical cord blood (UCB) contains stem cells and may be an alternative source to bone marrow and peripheral blood stem cells for allogeneic transplantation for the treatment of hematologic malignancies and genetic disorders. Many UCB banks have been established worldwide to quickly provide high quality materials for transplantation. Moreover, a detailed set of standards for cord blood banking have been drawn to guarantee the quality of the products. STUDY DESIGN AND METHODS: The aim of this study was to analyze our activity between 1998 and 2001, seeking to improve the number of suitable UCB units. Written informed consent was obtained from healthy women with an uncomplicated pregnancy. RESULTS: During the study period, we collected 1060 UCB units; 328 (31%) were banked, whereas 732 (69%) were discarded. The collections were performed in 73% vaginal deliveries and 27% of cesarean sections. The main reason for the exclusion was biological; in fact, a low number of nucleated cells and a low volume accounted for 71% of the total discarded units. Moreover, 20% of the units were discarded because of parental clinical reasons. CONCLUSIONS: Our study shows that maternal history must be completely reviewed before labor and obstetrical factors should be considered to improve the number of UCB units.
A Tamburini; C Malerba; A Picardi; S Amadori; A Calugi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation proceedings     Volume:  37     ISSN:  0041-1345     ISO Abbreviation:  Transplant. Proc.     Publication Date:    2005 Jul-Aug
Date Detail:
Created Date:  2005-09-26     Completed Date:  2006-01-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2670-2     Citation Subset:  IM    
Department of Hematology, University of Rome Tor Vergata, S. Eugenio Hospital, Rome, Italy.
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MeSH Terms
Cord Blood Stem Cell Transplantation / methods*
Fetal Blood / transplantation*
Living Donors
Patient Selection
Placenta / blood supply
Retrospective Studies
Tissue Banks
Transplantation, Homologous / methods

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