Document Detail


A cooperative polymer-DNA microarray approach to biomaterial investigation.
MedLine Citation:
PMID:  19156288     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, polymer microarrays were used for the rapid identification of polymer substrates upon which a suspension cell line would both adhere and proliferate giving a detailed and rapid understanding of cell-biomaterial interactions. Analysis demonstrated that suspension K562 human erythroleukemic cells, which normally grow in suspension, adhered and proliferated on several different polymers. Phenotypic and transcriptomic analysis techniques allowed examination of the interaction between cells and polymers permitting the elucidation of putative links between phenotypic responses to cell-biomaterial interactions and global gene expression.
Authors:
Salvatore Pernagallo; Juan Jose Diaz-Mochon; Mark Bradley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-14
Journal Detail:
Title:  Lab on a chip     Volume:  9     ISSN:  1473-0197     ISO Abbreviation:  Lab Chip     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-21     Completed Date:  2009-05-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128948     Medline TA:  Lab Chip     Country:  England    
Other Details:
Languages:  eng     Pagination:  397-403     Citation Subset:  IM    
Affiliation:
School of Chemistry, University of Edinburgh, EH9 3JJ, Edinburgh, UK.
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MeSH Terms
Descriptor/Qualifier:
Acrylic Resins / metabolism
Biocompatible Materials / metabolism*
Cell Adhesion* / genetics
Cell Proliferation
Gene Expression
Gene Expression Profiling
Humans
K562 Cells
Microarray Analysis / methods*
Microscopy, Acoustic
Oligonucleotide Array Sequence Analysis*
Phenotype
Polymers / metabolism*
Polyurethanes / metabolism
Reproducibility of Results
Chemical
Reg. No./Substance:
0/Acrylic Resins; 0/Biocompatible Materials; 0/Polymers; 0/Polyurethanes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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