Document Detail


Rearrangement/hypermutation/gene conversion: when, where and why?
MedLine Citation:
PMID:  8808057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diversification strategies for immunoglobulins vary widely in different species. Here, Jean-Claude Weill and Claude-Agnès Reynaud argue that V(D)J recombination arose as a means for achieving allelic exclusion rather than diversity, and postulate that the choice of a diversification strategy is selected along with a specific site of B-cell differentiation. They propose that somatic mutation and gene conversion represent analogous molecular strategies occurring in specific chromatin accessibility contexts.
Authors:
J C Weill; C A Reynaud
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Immunology today     Volume:  17     ISSN:  0167-5699     ISO Abbreviation:  Immunol. Today     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-10-25     Completed Date:  1996-10-25     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8008346     Medline TA:  Immunol Today     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  92-7     Citation Subset:  IM    
Affiliation:
INSERM U373, Faculté de Médecine Necker, Enfants Malades, Université Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
B-Lymphocytes / immunology*
Gene Rearrangement, B-Lymphocyte*
Genes, Immunoglobulin
Humans
Immunoglobulin Variable Region / genetics*
Mutation
Chemical
Reg. No./Substance:
0/Immunoglobulin Variable Region

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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