| The conversion of testosterone to 5 alpha-androstan-17 beta-ol-3-one (dihydrotestosterone) by skin slices of man. | |
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MedLine Citation:
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PMID: 5249746 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The conversion of testosterone-1,2-(3)H to dihydrotestosterone by slices of human skin obtained from various anatomical sites in 112 normal subjects and three individuals with the syndrome of testicular feminization has been measured under standardized conditions. Very low rates of dihydrotestosterone formation were observed in sites obtained from the mons or from miscellaneous areas of the trunk and limbs of the control subjects. The mean rates of conversion were very high, however, in slices of skin obtained from several perineal sites (labia majora, scrotum, prepuce, and clitoris). Furthermore, as measured here, the rate of dihydrotestosterone formation by prepuce rises during the 3 months after birth and then falls progressively thereafter, reaching a level in the adult that is almost as low as that observed in the slices of nonperineal skin from all ages. In the patients with testicular feminization dihydrotestosterone formation by slices of skin obtained from the mons was within the normal range, whereas the rates observed in labia majora were lower than the average values obtained in the normal subjects. |
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Authors:
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J D Wilson; J D Walker |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 48 ISSN: 0021-9738 ISO Abbreviation: J. Clin. Invest. Publication Date: 1969 Feb |
Date Detail:
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Created Date: 1969-03-20 Completed Date: 1969-03-20 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 371-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Androstanes / biosynthesis* Child Chromatography, Gas Chromatography, Thin Layer Clitoris Female Foot Genitalia, Female Humans Leg Male Melanoma Middle Aged Osteosarcoma Penis Scrotum Skin / metabolism* Testosterone / metabolism* Tritium |
| Chemical | |
Reg. No./Substance:
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0/Androstanes; 10028-17-8/Tritium; 58-22-0/Testosterone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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