| The convergence of type 1 and type 2 diabetes in childhood The accelerator hypothesis. | |
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MedLine Citation:
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PMID: 22059423 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Wilkin TJ. The accelerator hypothesis. It seems likely that type 1 and type 2 diabetes lie at different points of the same spectrum, separated by the misunderstanding that one belongs to childhood and the other to adulthood. The spectrum is that of tempo - the rate at which beta cell function is lost over time. A combination of beta cell up-regulation (insulin demand, largely determined by obesity) and the genetically-determined immune response to it ('autoimmunity') determines tempo, ranging from slow to fast with every variant in between. There is good evidence that people who go on to develop type 1 (fast) diabetes are, like those who develop type 2 (slow diabetes), insulin resistant, and overwhelming evidence that body mass plays a key role. The prevention of type 1 diabetes may lie in weight restriction from an early age. |
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Authors:
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Tj Wilkin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-8 |
Journal Detail:
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Title: Pediatric diabetes Volume: - ISSN: 1399-5448 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100939345 Medline TA: Pediatr Diabetes Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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University Medicine, Level 7, Derriford Hospital, Plymouth, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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