Document Detail

A convenient synthesis of 3 beta,12 alpha-, 3 beta,7 alpha-, and 3 beta,7 beta-dihydroxy-5-cholen-24-oic acids: unusual bile acids in human biological fluids.
MedLine Citation:
PMID:  3445285     Owner:  NLM     Status:  MEDLINE    
The unusual bile acids 3 beta,12 alpha- (V), 3 beta,7 alpha- (XIIIa), and 3 beta,7 beta- (XIIIb) dihydroxy-5-cholen-24-oic acids were synthesized conveniently from the 3-oxo derivatives of deoxycholic (I) and lithocholic (VI) acids, respectively, to provide authentic samples for the gas chromatography-mass spectrometric determination of these bile acids in the abnormal metabolism of bile acids.
M Tohma; R Mahara; H Takeshita; T Kurosawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Steroids     Volume:  48     ISSN:  0039-128X     ISO Abbreviation:  Steroids     Publication Date:    1986 Nov-Dec
Date Detail:
Created Date:  1988-04-25     Completed Date:  1988-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404536     Medline TA:  Steroids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  331-8     Citation Subset:  IM    
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University, Hokkaido, Japan.
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MeSH Terms
Bile Acids and Salts / analysis*
Body Fluids / analysis*
Chenodeoxycholic Acid / analogs & derivatives*,  analysis
Cholic Acids / analysis*
Gas Chromatography-Mass Spectrometry
Magnetic Resonance Spectroscopy
Reg. No./Substance:
0/Bile Acids and Salts; 0/Cholic Acids; 19246-13-0/3,7-dihydroxychol-5-enoic acid; 474-25-9/Chenodeoxycholic Acid; 63266-92-2/3,12-dihydroxy-5-cholenoic acid

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