Document Detail

A convenient solid-phase method for the synthesis of novel oligonucleotide-folate conjugates.
MedLine Citation:
PMID:  18066767     Owner:  NLM     Status:  MEDLINE    
We describe the preparation of two batches of a polymer support for the incorporation of folic acid into oligonucleotides. The method permits the regioselective attachment of a target nucleic acid sequence through its 3'-end to either the alpha-or gamma-carboxyl group of L-glutamic acid, respectively. The supports have been tested in solid-phase synthesis of oligonucleotide-folate conjugates for cell delivery studies.
Eugenia V Kazanova; Eugeny M Zubin; Anna V Kachalova; Eugeny M Volkov; Tatiana S Oretskaya; Dmitry A Stetsenko; Marina B Gottikh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nucleosides, nucleotides & nucleic acids     Volume:  26     ISSN:  1525-7770     ISO Abbreviation:  Nucleosides Nucleotides Nucleic Acids     Publication Date:  2007  
Date Detail:
Created Date:  2007-12-10     Completed Date:  2008-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892832     Medline TA:  Nucleosides Nucleotides Nucleic Acids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1273-6     Citation Subset:  IM    
Department of Chemistry and A. N. Belozersky Institute of Physico-Chemical Biology, M. V. Lomonossov Moscow State University, Moscow, Russia.
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MeSH Terms
Folic Acid / analysis,  chemistry*
Oligodeoxyribonucleotides / chemical synthesis*,  chemistry
Reg. No./Substance:
0/Oligodeoxyribonucleotides; 59-30-3/Folic Acid

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