Document Detail

A convenient method for regional monoamine oxidase-A determination by [14C]clorgyline autoradiography.
MedLine Citation:
PMID:  1522016     Owner:  NLM     Status:  MEDLINE    
The availability of clorgyline for regional monoamine oxidase-A (MAO-A) determination was examined using [14C]clorgyline in rat. [14C]Clorgyline was synthesized by the methylation reaction of N-desmethyl-clorgyline and [14C]methyliodide in dimethylformamide with high radiochemical yield. The MAO-A distribution map by autoradiography correlated with that by histochemical technique and its quantity was consistent with the calculated MAO-A amount based on previous reports. The combination of labeled clorgyline and autoradiographic technique will promise the quantitative measurement of regional MAO-A distribution.
M Murakami; Y Kondoh; Y Weimin; S Mizusawa; H Nakamichi; K Takahashi; H Sasaki; H Iida; S Miura; I Kanno
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology     Volume:  19     ISSN:  0883-2897     ISO Abbreviation:  Int J Rad Appl Instrum B     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-10-13     Completed Date:  1992-10-13     Revised Date:  2008-02-21    
Medline Journal Info:
Nlm Unique ID:  8611098     Medline TA:  Int J Rad Appl Instrum B     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  619-26     Citation Subset:  IM    
Department of Radiology, Research Institute for Brain and Blood Vessels-Akita, Japan.
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MeSH Terms
Autoradiography / methods*
Brain / enzymology
Carbon Radioisotopes / diagnostic use*
Clorgyline / chemical synthesis,  diagnostic use*
Monoamine Oxidase / analysis*
Rats, Inbred Strains
Tomography, Emission-Computed
Reg. No./Substance:
0/Carbon Radioisotopes; 17780-72-2/Clorgyline; EC Oxidase

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