Document Detail


A convenient method for the cleavage of the D-mannosyl-L-gulose disaccharide from bleomycin-A2.
MedLine Citation:
PMID:  2458835     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to elucidate the biological role of the sugar residue of the antitumor drug bleomycin, this was deglycosylated by beta-elimination under mild alkaline conditions, and by solvolysis with hydrogen fluoride. The latter procedure proved to be better because it led to the complete deglycosylation without modification of the peptide, thus allowing further biological investigations of this component.
Authors:
A Kenani; G Lamblin; J P Hénichart
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Carbohydrate research     Volume:  177     ISSN:  0008-6215     ISO Abbreviation:  Carbohydr. Res.     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-11-15     Completed Date:  1988-11-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0043535     Medline TA:  Carbohydr Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  81-9     Citation Subset:  IM    
Affiliation:
INSERM U-16, Lille, France.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / analysis
Bleomycin* / pharmacology
DNA Damage
Hydrolysis
Indicators and Reagents
Magnetic Resonance Spectroscopy
Plasmids / drug effects
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Indicators and Reagents; 11056-06-7/Bleomycin; 78314-57-5/deglycobleomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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