Document Detail


The controversial role of Sirtuins in tumorigenesis - SIRT7 joins the debate.
MedLine Citation:
PMID:  22847743     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sirtuins are NAD-dependent deacetylases that are conserved from yeast to mammals. A new report sheds light on the function of SIRT7, the least understood member of the Sirtuin family by identifying its locus-specific H3K18 deacetylase activity, and linking it to maintenance of cellular transformation in malignancies.
Authors:
Ling Li; Ravi Bhatia
Related Documents :
11771993 - Detection versus estimation in event-related fmri: choosing the optimal stimulus timing.
1575053 - Generalizations and extensions of the precue-utilization effect in rapid reactions.
8414893 - Both perceptual and conceptual factors influence taste-odor and taste-taste interactions.
Publication Detail:
Type:  Journal Article     Date:  2012-07-31
Journal Detail:
Title:  Cell research     Volume:  23     ISSN:  1748-7838     ISO Abbreviation:  Cell Res.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-03     Completed Date:  2013-06-18     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  9425763     Medline TA:  Cell Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  10-2     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acetylation
Animals
Cell Transformation, Neoplastic / genetics,  metabolism*,  pathology
Histones / genetics,  metabolism
Humans
Promoter Regions, Genetic
Ribosomal Proteins / metabolism
Sirtuins / metabolism*
ets-Domain Protein Elk-4 / metabolism
Chemical
Reg. No./Substance:
0/ELK4 protein, human; 0/Histones; 0/Ribosomal Proteins; 0/SIRT7 protein, human; 146481-62-1/ets-Domain Protein Elk-4; EC 3.5.1.-/Sirtuins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Chromatin-bound NLS proteins recruit membrane vesicles and nucleoporins for nuclear envelope assembl...
Next Document:  Resistance to EGFR blockade in colorectal cancer: liquid biopsies and latent subclones.