Document Detail

The controversial role of Sirtuins in tumorigenesis - SIRT7 joins the debate.
MedLine Citation:
PMID:  22847743     Owner:  NLM     Status:  MEDLINE    
Sirtuins are NAD-dependent deacetylases that are conserved from yeast to mammals. A new report sheds light on the function of SIRT7, the least understood member of the Sirtuin family by identifying its locus-specific H3K18 deacetylase activity, and linking it to maintenance of cellular transformation in malignancies.
Ling Li; Ravi Bhatia
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Publication Detail:
Type:  Journal Article     Date:  2012-07-31
Journal Detail:
Title:  Cell research     Volume:  23     ISSN:  1748-7838     ISO Abbreviation:  Cell Res.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-03     Completed Date:  2013-06-18     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  9425763     Medline TA:  Cell Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  10-2     Citation Subset:  IM    
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MeSH Terms
Cell Transformation, Neoplastic / genetics,  metabolism*,  pathology
Histones / genetics,  metabolism
Promoter Regions, Genetic
Ribosomal Proteins / metabolism
Sirtuins / metabolism*
ets-Domain Protein Elk-4 / metabolism
Reg. No./Substance:
0/ELK4 protein, human; 0/Histones; 0/Ribosomal Proteins; 0/SIRT7 protein, human; 146481-62-1/ets-Domain Protein Elk-4; EC 3.5.1.-/Sirtuins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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