| CSN5/Jab1 controls multiple events in the mammalian cell cycle. | |
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MedLine Citation:
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PMID: 20974137 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The COP9 signalosome (CSN) complex is critical for mammalian cell proliferation and survival, but it is not known how the CSN affects the cell cycle. In this study, MEFs lacking CSN5/Jab1 were generated using a CRE-flox system. MEFs ceased to proliferate upon elimination of CSN5/Jab1. Rescue experiments indicated that the JAMM domain of CSN5/Jab1 was essential. CSN5/Jab1-elimination enhanced the neddylation of cullins 1 and 4 and altered the expression of many factors including cyclin E and p53. CSN5/Jab1-elimination inhibited progression of the cell cycle at multiple points, seemed to initiate p53-independent senescence and increased the ploidy of cells. Thus, CSN5/Jab1 controls different events of the cell cycle, preventing senescence and endocycle as well as the proper progression of the somatic cell cycle. |
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Authors:
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Akihiro Yoshida; Noriko Yoneda-Kato; Martina Panattoni; Ruggero Pardi; Jun-ya Kato |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-26 |
Journal Detail:
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Title: FEBS letters Volume: 584 ISSN: 1873-3468 ISO Abbreviation: FEBS Lett. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-15 Completed Date: 2010-12-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 4545-52 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Animals Cell Cycle* Cell Cycle Proteins / metabolism Cell Proliferation Fibroblasts / cytology, metabolism Gene Knockdown Techniques Gene Silencing Genetic Loci / genetics HEK293 Cells Humans Intracellular Signaling Peptides and Proteins / chemistry, deficiency, genetics, metabolism* Mice Peptide Hydrolases / chemistry, deficiency, genetics, metabolism* Protein Structure, Tertiary Tumor Suppressor Protein p53 / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/Tumor Suppressor Protein p53; EC 3.4.-/Peptide Hydrolases; EC 3.4.-.-/Cops5 protein, mouse |
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