Document Detail

A controlled trial of intra-articular radiocolloids versus surgical synovectomy in persistent synovitis.
MedLine Citation:
PMID:  46959     Owner:  NLM     Status:  MEDLINE    
The results of a randomised trial of irradiation of the knee (synoviorthése), by intra-articular injection of yttrium-90, and surgical synovectomy have been compared in twenty knees in seventeen patients. The mean length of follow-up was 2 years. Relapse occurred in three out of ten irradiated knees, and in 2 out of 10 operated knees. Fewer irradiated knees were involved when generalised exacerbations of polyarthritis occurred. Irradiation carries a lower risk of complications than does synovectomy, it is more acceptable to patients, requires fewer days in hospital, and is cheaper; it would seem to be the treatment of choice in the older patient.
J M Gumpel; N C Roles
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Lancet     Volume:  1     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1975 Mar 
Date Detail:
Created Date:  1975-05-27     Completed Date:  1975-05-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  488-9     Citation Subset:  AIM; IM    
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MeSH Terms
Clinical Trials as Topic
Colloids / administration & dosage
Follow-Up Studies
Injections, Intra-Articular
Knee Joint* / physiopathology,  surgery
Length of Stay
Middle Aged
Radioisotopes / administration & dosage*,  therapeutic use
Synovial Membrane / surgery*
Synovitis / physiopathology,  radiotherapy,  surgery,  therapy*
Time Factors
Yttrium Isotopes / administration & dosage*,  therapeutic use
Reg. No./Substance:
0/Colloids; 0/Radioisotopes; 0/Yttrium Isotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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