| A controlled trial of colchicine in primary biliary cirrhosis. Trial design and preliminary report. | |
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MedLine Citation:
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PMID: 3655305 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Colchicine (1 mg/day), or an identical placebo, was given to 64 patients with primary biliary cirrhosis in a double-blind controlled trial. Due to a novel, pair-matched trial design, the two groups were exceptionally well matched at entry. In comparison with placebo, colchicine produced a beneficial effect on serum albumin and bilirubin levels at 3 months in patients who had abnormal liver function (bilirubin greater than 20 mumol/l) at entry: (albumin, P = 0.047; bilirubin, P = 0.022). In patients with normal liver function at entry (bilirubin less than 20 mumol/l), beneficial effects were noted on total globulin levels at 3 months (P = 0.013) and on immunoglobulin G levels at 3 and 6 months (P = 0.044 and 0.001, respectively). At 18 months, survival estimate in the colchicine and placebo groups were 84% and 69%, respectively. The difference did not reach significance. Colchicine produced an early improvement in liver function and immunoglobulin levels. Few serious side effects were encountered, and colchicine clearly merits long-term study in the treatment of primary biliary cirrhosis. |
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Authors:
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T W Warnes; A Smith; F I Lee; N Y Haboubi; P J Johnson; L Hunt |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of hepatology Volume: 5 ISSN: 0168-8278 ISO Abbreviation: J. Hepatol. Publication Date: 1987 Aug |
Date Detail:
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Created Date: 1987-11-06 Completed Date: 1987-11-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8503886 Medline TA: J Hepatol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 1-7 Citation Subset: IM |
Affiliation:
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University Department of Gastroenterology, Manchester Royal Infirmary, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bilirubin
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blood Colchicine / adverse effects, therapeutic use* Humans Immunoglobulins / analysis Liver Cirrhosis, Biliary / drug therapy*, immunology, pathology Serum Albumin / analysis Serum Globulins / analysis |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulins; 0/Serum Albumin; 0/Serum Globulins; 635-65-4/Bilirubin; 64-86-8/Colchicine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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