Document Detail

A controlled study of topical 0.25% timolol maleate gel for the treatment of cutaneous infantile capillary hemangiomas.
MedLine Citation:
PMID:  22410658     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the efficacy of topical 0.25% timolol maleate gel for the treatment of cutaneous infantile capillary hemangiomas.
METHODS: A retrospective, consecutive, nonrandomized, comparative single-masked cohort study of all patients presenting with nonvision-threatening periocular infantile capillary hemangiomas between August 2007 and January 2011 was performed. Parents chose twice daily topical 0.25% timolol maleate gel or observation. Photographs were taken at all visits and subsequently evaluated by masked examiners for change in lesion size, color, and thickness. Lesions were clinically defined as superficial, mixed, or deep. The primary outcome was response to treatment at 2 months, categorized as good (size decreased .50%), moderate (decrease 0-50%), or poor (enlarged or caused visually significant ptosis or induced astigmatism). The secondary outcome was response at latest follow-up visit.
RESULTS: Thirteen children received timolol, and 10 children were observed, with mean ages at presentation of 4.8 and 3.7 months (p 5 0.31), respectively. In the treated group, good response was observed in 8 (61.5%) infants, moderate response was seen in 4 (30.8%), and poor response was seen in one patient (7.7%). In the observed group, 0 (0%) demonstrated good response, one (10%) demonstrated moderate response, and 9 demonstrated poor response (90%) (p , 0.001). Responses were consistent on long-term follow-up (range 3-41 months). Both superficial (n 5 5; 100% good response) and mixed (n 5 7; 43% good, 57% moderate) lesions responded well to timolol; the one deep lesion did not. No adverse ocular or systemic effects were observed.
CONCLUSIONS: Topical timolol maleate gel 0.25% is effective in treatment of nonvision-threatening infantile capillary hemangiomas with a superficial component. Response at 2 months is stable over time.
Christopher B Chambers; William R Katowitz; James A Katowitz; Gil Binenbaum
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Publication Detail:
Type:  Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Ophthalmic plastic and reconstructive surgery     Volume:  28     ISSN:  1537-2677     ISO Abbreviation:  Ophthal Plast Reconstr Surg     Publication Date:    2012 Mar-Apr
Date Detail:
Created Date:  2012-03-13     Completed Date:  2012-06-01     Revised Date:  2013-05-08    
Medline Journal Info:
Nlm Unique ID:  8508431     Medline TA:  Ophthal Plast Reconstr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  103-6     Citation Subset:  IM    
Department of Ophthalmology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA.
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MeSH Terms
Administration, Topical
Adrenergic beta-Antagonists / administration & dosage*
Follow-Up Studies
Hemangioma, Capillary / drug therapy*,  pathology
Orbital Neoplasms / drug therapy*,  pathology
Retrospective Studies
Single-Blind Method
Skin Neoplasms / drug therapy*,  pathology
Timolol / administration & dosage*
Treatment Outcome
Visual Acuity / physiology
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Gels; 26839-75-8/Timolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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