| A controlled study of topical 0.25% timolol maleate gel for the treatment of cutaneous infantile capillary hemangiomas. | |
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MedLine Citation:
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PMID: 22410658 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the efficacy of topical 0.25% timolol maleate gel for the treatment of cutaneous infantile capillary hemangiomas. METHODS: A retrospective, consecutive, nonrandomized, comparative single-masked cohort study of all patients presenting with nonvision-threatening periocular infantile capillary hemangiomas between August 2007 and January 2011 was performed. Parents chose twice daily topical 0.25% timolol maleate gel or observation. Photographs were taken at all visits and subsequently evaluated by masked examiners for change in lesion size, color, and thickness. Lesions were clinically defined as superficial, mixed, or deep. The primary outcome was response to treatment at 2 months, categorized as good (size decreased .50%), moderate (decrease 0-50%), or poor (enlarged or caused visually significant ptosis or induced astigmatism). The secondary outcome was response at latest follow-up visit. RESULTS: Thirteen children received timolol, and 10 children were observed, with mean ages at presentation of 4.8 and 3.7 months (p 5 0.31), respectively. In the treated group, good response was observed in 8 (61.5%) infants, moderate response was seen in 4 (30.8%), and poor response was seen in one patient (7.7%). In the observed group, 0 (0%) demonstrated good response, one (10%) demonstrated moderate response, and 9 demonstrated poor response (90%) (p , 0.001). Responses were consistent on long-term follow-up (range 3-41 months). Both superficial (n 5 5; 100% good response) and mixed (n 5 7; 43% good, 57% moderate) lesions responded well to timolol; the one deep lesion did not. No adverse ocular or systemic effects were observed. CONCLUSIONS: Topical timolol maleate gel 0.25% is effective in treatment of nonvision-threatening infantile capillary hemangiomas with a superficial component. Response at 2 months is stable over time. |
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Authors:
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Christopher B Chambers; William R Katowitz; James A Katowitz; Gil Binenbaum |
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Publication Detail:
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Type: Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Ophthalmic plastic and reconstructive surgery Volume: 28 ISSN: 1537-2677 ISO Abbreviation: Ophthal Plast Reconstr Surg Publication Date: 2012 Mar-Apr |
Date Detail:
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Created Date: 2012-03-13 Completed Date: 2012-06-01 Revised Date: 2013-05-08 |
Medline Journal Info:
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Nlm Unique ID: 8508431 Medline TA: Ophthal Plast Reconstr Surg Country: United States |
Other Details:
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Languages: eng Pagination: 103-6 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA. christopher.chambers@northwestern.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adrenergic beta-Antagonists / administration & dosage* Follow-Up Studies Gels Hemangioma, Capillary / drug therapy*, pathology Humans Infant Orbital Neoplasms / drug therapy*, pathology Retrospective Studies Single-Blind Method Skin Neoplasms / drug therapy*, pathology Timolol / administration & dosage* Treatment Outcome Visual Acuity / physiology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Gels; 26839-75-8/Timolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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