| The control of kainic acid-induced status epilepticus. | |
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MedLine Citation:
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PMID: 20434312 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present study the effectiveness of different diazepam-ketamine combinations to control kainic acid-induced status epilepticus in rats was evaluated. We show that electrographic monitoring is mandatory to enable reliable assessment of status epilepticus control as the number of false positives is extremely high when status epilepticus control is only behaviourally assessed. Diazepam and ketamine synergistically blocked all electrographical seizure activity. |
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Authors:
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Katia Vermoesen; Ilse Smolders; Ann Massie; Yvette Michotte; Ralph Clinckers |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Epilepsy research Volume: 90 ISSN: 1872-6844 ISO Abbreviation: Epilepsy Res. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-23 Completed Date: 2010-09-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8703089 Medline TA: Epilepsy Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 164-6 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Pharmaceutical Chemistry and Drug Analysis, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticonvulsants / therapeutic use* Diazepam / therapeutic use* Disease Models, Animal Dose-Response Relationship, Drug Drug Synergism Electroencephalography / methods Excitatory Amino Acid Antagonists / therapeutic use* Kainic Acid Ketamine / therapeutic use* Male Rats Rats, Wistar Status Epilepticus / chemically induced, drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Excitatory Amino Acid Antagonists; 439-14-5/Diazepam; 487-79-6/Kainic Acid; 6740-88-1/Ketamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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