Document Detail

The control of EGF signaling and cell fate in the Drosophila abdomen.
MedLine Citation:
PMID:  18948759     Owner:  NLM     Status:  Publisher    
How cells integrate both patterning and signaling information to select between distinct cell fates is a fundamental problem in developmental biology. In this short review, I focus on recent findings of how the Hox and senseless patterning genes regulate epidermal growth factor (EGF) signaling and cell fate within the Drosophila abdomen. In Li-Kroeger et al., we described how a Hox and Senseless transcription factor competition functions as a molecular switch on a cis-regulatory element in the rhomboid (rho) gene to control EGF signaling within the peripheral nervous system (PNS). Here, I discuss an additional implication of these findings: that rho contains at least two cis-regulatory elements to control EGF secretion from the PNS, each to induce a different cell fate.
Brian Gebelein
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2008-9-25
Journal Detail:
Title:  Fly     Volume:  2     ISSN:  1933-6942     ISO Abbreviation:  Fly (Austin)     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-10-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101470897     Medline TA:  Fly (Austin)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Division of Developmental Biology, Cincinnati Children's Hospital, Cincinnati, Ohio, USA.
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