Document Detail

The contributions of renin and vasopressin to the adaptation of the Australian spinifex hopping mouse (Notomys alexis) to free water deprivation.
MedLine Citation:
PMID:  7915648     Owner:  NLM     Status:  MEDLINE    
Xeric-adaptation was studied during 28 days of total water deprivation (TWD) in Notomys alexis. Beyond 7 days, the initial reductions in body weight and increases in haematocrit, plasma renin and juxtaglomerular (JG) cell morphological activity returned to normal. Mus musculus showed similar changes at 7 days but could not be maintained thereafter. TWD decreased the blood pressure of Notomys but endogenous angiotensin and vasopressin did not support pressure to a greater extent than controls, as revealed by selective antagonists. The normal morphology of the JG apparatus in Notomys was similar to other rodents. Fluid volume and blood pressure maintenance during TWD in Notomys do not depend upon enhanced activities of the renin-angiotensin and antidiuretic hormonal systems.
D Weaver; L Walker; D Alcorn; S Skinner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Comparative biochemistry and physiology. Comparative physiology     Volume:  108     ISSN:  -     ISO Abbreviation:  Comp. Biochem. Physiol. Comp. Physiol.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-09-30     Completed Date:  1994-09-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9441449     Medline TA:  Comp Biochem Physiol Comp Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  107-16     Citation Subset:  IM    
Department of Physiology, University of Melbourne, Parkville, Australia.
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MeSH Terms
Adaptation, Physiological / physiology*
Arginine Vasopressin / analogs & derivatives,  pharmacology
Blood Pressure / drug effects,  physiology
Body Weight / physiology
Enalaprilat / pharmacology
Juxtaglomerular Apparatus / physiology
Mice / physiology
Mice, Inbred BALB C
Renin / physiology*
Rodentia / physiology*
Saralasin / pharmacology
Vasopressins / physiology*
Water Deprivation / physiology*
Reg. No./Substance:
11000-17-2/Vasopressins; 113-79-1/Arginine Vasopressin; 34273-10-4/Saralasin; 73168-23-7/argipressin, beta-mercapto-beta,beta cyclopentamethylenepropionic acid(1)-; 84680-54-6/Enalaprilat; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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