Document Detail


The contribution of tremor studies to diagnosis of parkinsonian and essential tremor: a statistical evaluation.
MedLine Citation:
PMID:  12093126     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study statistically evaluated a set of commonly measured tremor parameters to determine their individual and combined ability to discriminate between essential tremor (ET) and Parkinsonian tremor (PT). Accelerometer and surface electromyographic (EMG) records of moderate to severe upper limb tremor in 20 patients with ET and 22 patients with PT were used to quantitatively compare tremor amplitude, frequency and pattern of muscle bursting in two resting and three non resting postures. The group statistics showed significant differences between ET and PT with respect to tremor frequency in all five postures, tremor amplitude at rest and muscle bursting patterns. Discriminant function analysis showed that no single parameter or combination of parameters was able to correctly classify all patients. Frequency was much more discriminating than amplitude or muscle bursting patterns in all limb postures. The best amplitude discrimination was obtained when the hand and forearm were both fully supported. Muscle bursting patterns were poorly discriminating and did not assist in correct classification of single patients. Group statistics confirmed a highly significant biological difference between the two tremor types. Optimal classification of single PT (86% correct) and ET (95% correct) patients was obtained using frequency and two selected amplitude parameters from the resting limb. Limb posture was an important variable in optimising the discriminative ability of tremor studies. The implications for routine tremor studies are summarised.
Authors:
J A Burne; M W Hayes; V S C Fung; C Yiannikas; D Boljevac
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia     Volume:  9     ISSN:  0967-5868     ISO Abbreviation:  J Clin Neurosci     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-07-02     Completed Date:  2002-10-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9433352     Medline TA:  J Clin Neurosci     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  237-42     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Published by Elsevier Science Ltd.
Affiliation:
Department of Neurology, Westmead Hospital, Westmead, NSW, Australia. J.Burne@cchs.usyd.edu.au
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Arm
Discriminant Analysis
Electromyography
Humans
Middle Aged
Muscle, Skeletal / physiopathology
Parkinsonian Disorders / diagnosis*,  physiopathology
Posture
Rest
Tremor / diagnosis*,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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