Document Detail


The contribution of three strong candidate schizophrenia susceptibility genes in demographically distinct populations.
MedLine Citation:
PMID:  15248869     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Here we characterize and compare the contribution of three recently identified strong candidate schizophrenia susceptibility genes; G72, neuregulin 1 (NRG1) and dystrobrevin-binding protein 1 (DTNBP1) in two independent datasets of patients with distinct genetic backgrounds. On the basis of corrected P-values from single- and multilocus transmission distortion tests our analysis provides no support for a contribution of G72, NRG1 or DTNBP1 in the tested samples. When transmission of individual haplotypes was considered, a picture more consistent with the original studies emerged, where transmission distortions in the same direction as the original samples and involving the same core haplotypes were observed for G72 and NRG1. Interestingly, whereas the NRG1 gene analysis was dominated by the presence of over-transmitted haplotypes, the G72 gene analysis was consistently dominated in both datasets by under-transmissions. Negative transmissions involved a core haplotype complementary to the originally detected over-transmitted haplotype, suggesting the presence of a protective variant within the G72 locus.
Authors:
D Hall; J A Gogos; M Karayiorgou
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genes, brain, and behavior     Volume:  3     ISSN:  1601-1848     ISO Abbreviation:  Genes Brain Behav.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-13     Completed Date:  2004-10-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101129617     Medline TA:  Genes Brain Behav     Country:  England    
Other Details:
Languages:  eng     Pagination:  240-8     Citation Subset:  IM    
Affiliation:
The Rockefeller University, Human Neurogenetics Laboratory, New York, NY 10021, USA.
Data Bank Information
Bank Name/Acc. No.:
OMIM/142445;  181500;  607145;  607408
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MeSH Terms
Descriptor/Qualifier:
Carrier Proteins / genetics*
Genetic Predisposition to Disease*
Genetic Variation
Humans
Neuregulin-1 / genetics*
Pedigree
Schizophrenia / epidemiology,  genetics*
South Africa / epidemiology
United States / epidemiology
Grant Support
ID/Acronym/Agency:
M01 RR00102/RR/NCRR NIH HHS; MH61399/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/DAOA protein, human; 0/DTNBP1 protein, human; 0/Neuregulin-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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