Document Detail

The contribution of prostaglandins versus prostacyclin in ventricular remodeling during heart failure.
MedLine Citation:
PMID:  21855554     Owner:  NLM     Status:  MEDLINE    
Although the role of Cox-2 in the heart's response to physiologic stress remains controversial (i.e. expression in myocytes versus other resident myocardial cells) the ever expanding role of prostanoids in multiple models of heart failure cannot be denied. Due to the fact that prostanoids are metabolized rather quickly (half life of seconds to minutes) it is believed these signaling mediators act in a paracrine fashion at the site of production. Evidence to date is quite convincing that these bioactive lipid derivatives are involved in physiologic homeostatic regulation as well as beneficial and maladaptive ventricular remodeling in heart failure. Thus, this review will assess the direct contribution of each PG on remodeling in the left ventricle (e.g. hypertrophy, functional effects, and fibrosis).
Pamela Harding; David B Murray
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-08-10
Journal Detail:
Title:  Life sciences     Volume:  89     ISSN:  1879-0631     ISO Abbreviation:  Life Sci.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-21     Completed Date:  2011-12-02     Revised Date:  2013-09-16    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  671-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Hospital, Detroit, MI 48202, USA.
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MeSH Terms
Epoprostenol / metabolism*
Heart Failure / physiopathology*
Prostaglandins / metabolism*
Ventricular Function, Left
Ventricular Remodeling*
Grant Support
Reg. No./Substance:
0/Prostaglandins; 35121-78-9/Epoprostenol

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