Document Detail

The contribution of plant foods to the vitamin A supply of lactating women in Vietnam: a randomized controlled trial.
MedLine Citation:
PMID:  17413113     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: More information is needed on the efficacy of carotenoids from plant foods in improving vitamin A status. OBJECTIVE: We aimed to quantify the efficacy of provitamin A-rich vegetables and fruit in improving vitamin A status. DESIGN: Breastfeeding women in 9 rural communes in Vietnam were randomly allocated to 1 of 4 groups: the vegetable group (n = 73), which ingested 5.6 mg beta-carotene/d from green leafy vegetables; the fruit group (n = 69), which ingested 4.8 mg beta-carotene/d from orange or yellow fruit; the retinol-rich group (n = 70), which ingested 610 microg retinol/d from animal foods and 0.6 mg beta-carotene/d; and the control group (n = 68), which ingested 0.4 mg beta-carotene/d. Meals of groups 1, 2, and 4 contained <30 microg retinol/d. Lunch and dinner were provided 6 d/wk for 10 wk. RESULTS: Mean (95% CI) changes in serum retinol concentrations of the vegetable, fruit, retinol-rich, and control groups were 0.09 (0.03, 0.16), 0.13 (0.07, 0.19), 0.25 (0.17, 0.33), and 0.00 (-0.06, 0.06) micromol/L, respectively. Mean (95% CI) changes in breast-milk retinol concentrations were 0.15 (0.04, 0.27), 0.15 (0.02, 0.28), 0.48 (0.32, 0.64), and -0.06 (-0.21, 0.09) micromol/L, respectively. According to these findings, the equivalent of 1 microg retinol would be 12 microg beta-carotene (95% CI: 8, 22 microg) for fruit and 28 microg beta-carotene (17, 84 microg) for green leafy vegetables. Thus, apparent mean vitamin A activity of carotenoids in fruit and in leafy vegetables was 50% (95% CI: 27%, 75%) and 21% (7%, 35%), respectively, of that assumed. CONCLUSION: The bioavailability of carotenoids from vegetables and fruit is less than previously assumed.
Nguyen Cong Khan; Clive E West; Saskia de Pee; Diane Bosch; Ha Do Phuong; Paul Jm Hulshof; Ha Huy Khoi; Hans Verhoef; Joseph Gaj Hautvast
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  85     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-06     Completed Date:  2007-05-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1112-20     Citation Subset:  AIM; IM    
National Institute of Nutrition, Hanoi, Vietnam.
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MeSH Terms
Biological Availability
Carotenoids / administration & dosage,  pharmacokinetics
Fruit* / chemistry
Intestinal Absorption
Lactation / metabolism*
Milk, Human / chemistry*,  drug effects
Nutritional Requirements
Nutritional Status
Rural Population
Vegetables* / chemistry
Vitamin A / administration & dosage*,  pharmacokinetics*
Vitamins / administration & dosage,  pharmacokinetics
Reg. No./Substance:
0/Vitamins; 11103-57-4/Vitamin A; 36-88-4/Carotenoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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