Document Detail

The contribution of peripheral chemoreceptors to ventilation during heavy exercise.
MedLine Citation:
PMID:  3602617     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to determine, in man, the contribution of peripheral chemoreceptors to ventilation during constant-load, heavy exercise above anaerobic threshold at sea level, using hyperoxic suppression of peripheral chemoreceptor drive which was obtained by abrupt and surreptitious replacement of inspired air with 100% oxygen for a period of 20-30 sec during the exercise. There was a delay of at least 1 sec from the time of peripheral chemoreceptor blockade to the initial change in ventilation, suggesting the operation of a central neural reverberatory mechanism after the cessation of peripheral chemoreceptor drive. In contrast to Wasserman (1976), whose results indicated a 25% decrease in ventilation within two breaths, in the present study no significant drop was observed until some 4-6 breaths after the air-to-oxygen switch. Furthermore, the drop in ventilation, magnitude of which was of the order of 15%, was transient in 5 out of 8 subjects. In one subject, the ventilation increased following oxygen administration. It is concluded that the peripheral chemoreceptors are not the sole mediators of hyperventilation of heavy exercise above anaerobic threshold in man.
R Jeyaranjan; R Goode; S Beamish; J Duffin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration physiology     Volume:  68     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-08-04     Completed Date:  1987-08-04     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  203-13     Citation Subset:  IM; S    
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MeSH Terms
Acidosis / physiopathology
Blood Circulation Time
Carotid Body / physiology
Chemoreceptor Cells / physiology*
Oxygen / physiology
Physical Exertion*
Reg. No./Substance:

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