Document Detail

The contribution of new findings and ideas to the old principles of teratology.
MedLine Citation:
PMID:  15967633     Owner:  NLM     Status:  MEDLINE    
Although the last generally accepted concept of principles of teratology was issued more than 30 years ago, the cause of less than 50% of all congenital anomalies is known and no substantial change in their incidence has been observed worldwide. In the meantime, powerful techniques of molecular biology as well as many sophisticated preventive measures have been introduced with marginal effects on the overall birth defects numbers. In this paper, we follow the history of basic concepts of teratology starting with Isidore Geoffroy Saint-Hilaire and Dareste, followed in the 20th century by James Wilson. Since that time no bright and completely new idea, which would deserve the name principle, has emerged. The advanced molecular studies support the long-existing principles and disclose the great variability of individuals and their responses to adverse exposures. In this way, the future of teratology counseling may be seen in a deep analysis of any individual case.
Richard Jelínek
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Publication Detail:
Type:  Historical Article; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  20     ISSN:  0890-6238     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:    2005 Sep-Oct
Date Detail:
Created Date:  2005-07-11     Completed Date:  2005-09-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  295-300     Citation Subset:  IM    
Department of Histology and Embryology, Charles University 3rd Faculty of Medicine, Ruská 87, 100 00 Praha 10, Prague, Czech Republic.
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MeSH Terms
Congenital Abnormalities / etiology*,  genetics
History, 19th Century
History, 20th Century
History, 21st Century
Molecular Biology*
Risk Assessment
Teratology* / history,  methods

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