Document Detail


The contribution of new findings and ideas to the old principles of teratology.
MedLine Citation:
PMID:  15967633     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although the last generally accepted concept of principles of teratology was issued more than 30 years ago, the cause of less than 50% of all congenital anomalies is known and no substantial change in their incidence has been observed worldwide. In the meantime, powerful techniques of molecular biology as well as many sophisticated preventive measures have been introduced with marginal effects on the overall birth defects numbers. In this paper, we follow the history of basic concepts of teratology starting with Isidore Geoffroy Saint-Hilaire and Dareste, followed in the 20th century by James Wilson. Since that time no bright and completely new idea, which would deserve the name principle, has emerged. The advanced molecular studies support the long-existing principles and disclose the great variability of individuals and their responses to adverse exposures. In this way, the future of teratology counseling may be seen in a deep analysis of any individual case.
Authors:
Richard Jelínek
Related Documents :
9668403 - Prenatal cocaine exposure. a longitudinal study of development.
24716033 - Necrotizing fasciitis complicating pregnancy: a case report and literature review.
7149743 - Papular dermatitis of pregnancy.
Publication Detail:
Type:  Historical Article; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  20     ISSN:  0890-6238     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:    2005 Sep-Oct
Date Detail:
Created Date:  2005-07-11     Completed Date:  2005-09-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  295-300     Citation Subset:  IM    
Affiliation:
Department of Histology and Embryology, Charles University 3rd Faculty of Medicine, Ruská 87, 100 00 Praha 10, Prague, Czech Republic. richard.jelinek@lf3.cuni.cz
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Congenital Abnormalities / etiology*,  genetics
Female
History, 19th Century
History, 20th Century
History, 21st Century
Humans
Molecular Biology*
Pregnancy
Risk Assessment
Teratology* / history,  methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Human embryonic stem cells: genetic manipulation on the way to cardiac cell therapies.
Next Document:  Teratogenic effects of diphenyl diselenide in Wistar rats.