| The contribution of neuroimaging for the study of cognitive deficits in Parkinson's disease. | |
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MedLine Citation:
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PMID: 20521489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The last few years have seen an increase in the number of studies using functional Magnetic Resonance Imaging (fMRI) along with receptor imaging and regional cerebral blood flow Positron Emission Tomography (PET) to understand the neurobiological underpinnings of cognitive deficits in Parkinson's disease (PD). These studies have shown evidence that the nigrostriatal degeneration solely cannot account for these deficits and that involvement of other neural systems such as the mesocortical dopamine may also play an important role. In this article, we provide a review of neuroimaging results regarding the role of possible compensatory activity, L-Dopa medication, and difference in genotypes on the cognitive deficits observed in PD. Finally, some future avenues for research are proposed. |
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Authors:
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Oury Monchi; Kristina Martinu; Antonio P Strafella |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical EEG and neuroscience : official journal of the EEG and Clinical Neuroscience Society (ENCS) Volume: 41 ISSN: 1550-0594 ISO Abbreviation: Clin EEG Neurosci Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-06-04 Completed Date: 2010-07-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101213033 Medline TA: Clin EEG Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 76-81 Citation Subset: IM |
Affiliation:
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Functional Neuroimaging Unit, Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada. oury.monchi@umontreal.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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physiopathology* Brain Mapping / methods* Cognition Disorders / diagnosis, etiology*, physiopathology* Humans Neuroradiography / trends* Parkinson Disease / complications*, diagnosis, physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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/MOP-81114//Canadian Institutes of Health Research |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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