Document Detail

The contribution of hemolysis to early jaundice in normal newborns.
MedLine Citation:
PMID:  16818575     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Neonatal jaundice is the result of an imbalance between bilirubin production and elimination, and our objective was to clarify the contribution of an increase in bilirubin production to hyperbilirubinemia in newborns. METHODS: We measured the end-tidal carbon monoxide concentration corrected for ambient carbon monoxide concentration in 108 jaundiced newborns (total serum bilirubin level >75th percentile) and 164 control newborns in our well-infant nursery, for the first 4 days after birth. RESULTS: Mean end-tidal carbon monoxide levels decreased in the control infants in the first 4 days but increased in the hyperbilirubinemic group. The differences between the jaundiced and nonjaundiced infants were statistically significant on all days. CONCLUSIONS: Before hospital discharge, most infants with bilirubin levels >75th percentile are producing significantly more bilirubin than those with lower bilirubin levels. Because the ability of newborns to conjugate bilirubin is significantly impaired in the first few days, even a small increase in the rate of production can contribute to the development of hyperbilirubinemia. These data suggest that increased heme catabolism is an important mechanism responsible for hyperbilirubinemia in the first 4 days after birth.
M Jeffrey Maisels; Elizabeth Kring
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatrics     Volume:  118     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-04     Completed Date:  2006-08-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  276-9     Citation Subset:  AIM; IM    
Department of Pediatrics, William Beaumont Hospital, 3601 W 13 Mile Rd, Royal Oak, Michigan 48073, USA.
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MeSH Terms
Bilirubin / metabolism
Birth Weight
Carbon Monoxide / analysis*
Gestational Age
Heme / metabolism
Infant, Newborn
Jaundice, Neonatal / metabolism,  physiopathology*
Reg. No./Substance:
14875-96-8/Heme; 630-08-0/Carbon Monoxide; 635-65-4/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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