Document Detail


The contribution of cervical propriospinal premotoneurons in recovering hemiparetic stroke patients.
MedLine Citation:
PMID:  15622129     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is evidence in humans that the C3/4 level of the spinal cord is a site for sensorimotor integration, analogous to the C3/4 propriospinal system (PS) in cat. Although the clinical relevance of the putative C3/4 PS in humans is not clear, there is some evidence indicating that drive to upper limb muscles via this nonmonosynaptic pathway is upregulated as a compensatory mechanism in stroke and in Parkinson's disease. The authors investigated whether descending drive via the C3/4 PS to affected limb wrist flexors of moderately to well-recovered chronic stroke patients is upregulated compared with controls. The extent of descending drive via the C3/4 PS was assessed in seven patients and seven control subjects during the onset of cocontraction of the biceps brachii and flexor carpi radialis (FCR), during which transcranial magnetic stimulation was used to evoke motor potentials in FCR. Responses were conditioned by subthreshold stimulation of the musculocutaneous nerve. The extent of this facilitation was taken as a measure of the proportion of drive to FCR motoneurons being transmitted via the C3/4 PS. Patients revealed greater facilitation than control subjects, suggesting that descending drive to forearm flexors was being transmitted via the C3/4 PS as a compensation mechanism after stroke.
Authors:
James W Stinear; Winston D Byblow
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society     Volume:  21     ISSN:  0736-0258     ISO Abbreviation:  J Clin Neurophysiol     Publication Date:    2004 Nov-Dec
Date Detail:
Created Date:  2004-12-28     Completed Date:  2005-02-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8506708     Medline TA:  J Clin Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  426-34     Citation Subset:  IM    
Affiliation:
Human Motor Control Laboratory, Department of Sport and Exercise Science, University of Auckland, Auckland, New Zealand. j-stinear@northwestern.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Cervical Vertebrae
Electric Stimulation
Electromyography
Evoked Potentials, Motor / physiology
Female
Humans
Magnetics
Male
Middle Aged
Motor Neurons / physiology*
Paresis / physiopathology*
Proprioception / physiology
Recovery of Function / physiology
Spinal Cord / cytology*,  physiology*
Stroke / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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