| The contribution of cervical propriospinal premotoneurons in recovering hemiparetic stroke patients. | |
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MedLine Citation:
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PMID: 15622129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is evidence in humans that the C3/4 level of the spinal cord is a site for sensorimotor integration, analogous to the C3/4 propriospinal system (PS) in cat. Although the clinical relevance of the putative C3/4 PS in humans is not clear, there is some evidence indicating that drive to upper limb muscles via this nonmonosynaptic pathway is upregulated as a compensatory mechanism in stroke and in Parkinson's disease. The authors investigated whether descending drive via the C3/4 PS to affected limb wrist flexors of moderately to well-recovered chronic stroke patients is upregulated compared with controls. The extent of descending drive via the C3/4 PS was assessed in seven patients and seven control subjects during the onset of cocontraction of the biceps brachii and flexor carpi radialis (FCR), during which transcranial magnetic stimulation was used to evoke motor potentials in FCR. Responses were conditioned by subthreshold stimulation of the musculocutaneous nerve. The extent of this facilitation was taken as a measure of the proportion of drive to FCR motoneurons being transmitted via the C3/4 PS. Patients revealed greater facilitation than control subjects, suggesting that descending drive to forearm flexors was being transmitted via the C3/4 PS as a compensation mechanism after stroke. |
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Authors:
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James W Stinear; Winston D Byblow |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society Volume: 21 ISSN: 0736-0258 ISO Abbreviation: J Clin Neurophysiol Publication Date: 2004 Nov-Dec |
Date Detail:
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Created Date: 2004-12-28 Completed Date: 2005-02-25 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8506708 Medline TA: J Clin Neurophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 426-34 Citation Subset: IM |
Affiliation:
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Human Motor Control Laboratory, Department of Sport and Exercise Science, University of Auckland, Auckland, New Zealand. j-stinear@northwestern.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cervical Vertebrae Electric Stimulation Electromyography Evoked Potentials, Motor / physiology Female Humans Magnetics Male Middle Aged Motor Neurons / physiology* Paresis / physiopathology* Proprioception / physiology Recovery of Function / physiology Spinal Cord / cytology*, physiology* Stroke / physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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