Document Detail


The contribution of birth defects to spontaneous preterm birth.
MedLine Citation:
PMID:  17992716     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to determine if and which birth defects (BDs) are risk factors for spontaneous preterm delivery, and to quantify that risk. A case-control study of spontaneously delivered term (n = 21,093) and preterm (n = 2937; 12.2%) liveborn neonates, between 1996 and 2000, at Ramón Sardá Maternity Hospital of Buenos Aires, was performed. Selected risk factors were compared between term and preterm neonates, and risks of preterm birth in the presence of BDs were evaluated, using stratified and logistic regression analyses. Preterm versus term neonates showed higher rates of most of the selected maternal and neonatal risk factors. The prevalence of BDs among preterm and term neonates was 4.1 and 2.0%, respectively (p < 0.001). Newborns with BDs showed a higher adjusted risk for preterm birth than those without BDs (odds ratio, 2.16; 95% confidence interval, 1.92 to 2.40), with the highest risks for skeletal dysplasias, abdominal wall defects, chromosome, multiple, and minor anomalies. That neonates with BDs are at risk for spontaneous preterm birth, regardless of other factors, should lead to a readjustment of health policies aimed at the reduction of preterm delivery.
Authors:
Carlos Grandi; Guillermo Luchtenberg; Monica Rittler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of perinatology     Volume:  24     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-11-08     Completed Date:  2007-12-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  487-92     Citation Subset:  IM    
Affiliation:
Perinatal Epidemiology and Biostatistics Unit, Hospital Materno Infantil Ramón Sardá, Buenos Aires, Argentina.
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Congenital Abnormalities / epidemiology*
Female
Gestational Age
Humans
Infant, Newborn
Male
Odds Ratio
Pregnancy
Premature Birth / epidemiology,  etiology*
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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