Document Detail

The contribution of HIV infection to intracranial arterial remodeling: a pilot study.
MedLine Citation:
PMID:  23067346     Owner:  NLM     Status:  MEDLINE    
Pathological arterial wall changes have been cited as potential mechanisms of cerebrovascular disease in the HIV population. We hypothesize that dilatation would be present in arterial walls of patients with HIV compared to controls. Fifty-one intracranial arteries, obtained from autopsies of five individuals with HIV infection and 13 without, were fixed, embedded, stained, and digitally photographed. Cross-sectional areas of intima, media, adventitia and lumen were measured by preset color thresholding. A measure of arterial remodeling was obtained by calculating the ratio between the lumen diameter and the thickness of the arterial wall. Higher numbers indicate arterial dilatation, while lower numbers indicate arterial narrowing. HIV-infected brain donors were more frequently black (80% vs. 15%, P = 0.02) compared with uninfected donors. Inter and intra-reader agreement measures were excellent. The continuous measure of vascular remodeling was significantly higher in the arteries from HIV donors (β = 2.8, P = 0.02). Adjustments for demographics and clinical covariates strengthen this association (β = 9.3, P = 0.01). We found an association of HIV infection with outward brain arterial remodeling. This association might be mediated by a thinner media layer. The reproduction of these results and the implications of this proposed pathophysiology merits further study.
Jose Gutierrez; Mitchell S V Elkind; Carol Petito; David Y Chung; Andrew J Dwork; Randolph S Marshall
Related Documents :
18625696 - Host- rather than virus-related factors reduce health-related quality of life in hepati...
24754376 - Seroprevalence of occult hepatitis b among egyptian paediatric hepatitis c cancer patie...
22994166 - Effectiveness of a risk screener in identifying hepatitis c virus in a primary care set...
24518976 - Dental caries prevalence in human immunodeficiency virus infected patients receiving hi...
1783356 - Hepatitis c virus is a more likely cause of chronic liver disease in the japanese popul...
24967706 - Modeling neutralization kinetics of hiv by broadly neutralizing monoclonal antibodies i...
Publication Detail:
Type:  Journal Article     Date:  2012-10-15
Journal Detail:
Title:  Neuropathology : official journal of the Japanese Society of Neuropathology     Volume:  33     ISSN:  1440-1789     ISO Abbreviation:  Neuropathology     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-03     Completed Date:  2014-01-10     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  9606526     Medline TA:  Neuropathology     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  256-63     Citation Subset:  IM    
Copyright Information:
© 2012 Japanese Society of Neuropathology.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
African Continental Ancestry Group
Cerebral Arteries / pathology*
European Continental Ancestry Group
HIV Infections / pathology*
Middle Aged
Paraffin Embedding
Pilot Projects
Vascular Stiffness
Vasodilation / physiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Foot pain and functional limitation in healthy adults with hallux valgus: a cross-sectional study.
Next Document:  Neonatal intrahepatic cholestasis caused by citrin deficiency: prevalence and SLC25A13 mutations amo...