Document Detail


The contribution of 18F-FDG PET in preoperative epilepsy surgery evaluation for patients with temporal lobe epilepsy A meta-analysis.
MedLine Citation:
PMID:  17532231     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess the predictive diagnostic added value of positron emission tomography (PET) in preoperative epilepsy surgery evaluation for patients with temporal lobe epilepsy (TLE). METHODS: A meta-analysis of publications from 1992 to 2006 was performed. Forty-six studies were identified that met inclusion criteria presenting detailed diagnostic test results and a classified postoperative outcome. Studies exclusively reporting on patients with brain tumors or on children were excluded. RESULTS: The analyses were complicated by significant differences in study design and often by lack of precise patient data. Ipsilateral PET hypometabolism showed a predictive value of 86% for good outcome. The predictive value was 80% in patients with normal MRI and 72% in patients with non-localized ictal scalp EEG. In a selected population of 153 TLE patients with a follow-up of >12 months PET correlated well with other non-invasive diagnostic tests, but none of the odds ratios of any test combination was significant. CONCLUSION: Our data confirm that ipsilateral PET hypometabolism may be an indicator for good postoperative outcome in presurgical evaluation of drug-resistant TLE, although the actual diagnostic added value remained questionable and unclear. PET does not appear to add value in patients localized by ictal scalp EEG and MRI. Prospective studies limited to non-localized ictal scalp EEG or MRI-negative patients are required for validation.
Authors:
O Willmann; R Wennberg; T May; F G Woermann; B Pohlmann-Eden
Publication Detail:
Type:  Evaluation Studies; Journal Article; Meta-Analysis     Date:  2007-05-25
Journal Detail:
Title:  Seizure : the journal of the British Epilepsy Association     Volume:  16     ISSN:  1059-1311     ISO Abbreviation:  Seizure     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-13     Completed Date:  2007-11-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9306979     Medline TA:  Seizure     Country:  England    
Other Details:
Languages:  eng     Pagination:  509-20     Citation Subset:  IM    
Affiliation:
Department of Neurology, University Hospital Mannheim, University of Heidelberg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Electroencephalography / methods
Epilepsy, Temporal Lobe / radionuclide imaging*
Female
Fluorodeoxyglucose F18 / diagnostic use*
Humans
Magnetic Resonance Imaging
Male
Positron-Emission Tomography / methods*
Preoperative Care*
PubMed / statistics & numerical data
Radiopharmaceuticals / diagnostic use*
Chemical
Reg. No./Substance:
0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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