| The contrasting characteristics of acute kidney injury in developed and developing countries. | |
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MedLine Citation:
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PMID: 18212780 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute kidney injury (AKI) has become increasingly prevalent in both developed and developing countries, and is associated with severe morbidity and mortality, especially in children. Uncertainty regarding the true incidence of AKI limits awareness of the problem, thereby reducing political visibility of the disorder and hampering efforts to prevent its occurrence. In developed countries, AKI occurs predominantly in urban intensive care units and is associated with multiorgan failure and sepsis, high mortality, and occurrence in older populations. While cases of AKI in urban areas of the developing world have similar characteristics to those in the developed world, AKI in rural regions commonly develops in response to a single disease and specific conditions (e.g. gastroenteritis) or infections (e.g. severe malaria, leptospirosis, or hemolytic-uremic syndrome) and in younger otherwise healthy individuals. Many causes of AKI in rural settings, such as diarrhea, poisoning, malaria, or septic abortion, can be prevented by interventions at the individual, community, and regional levels. Treatment with dialysis is often unavailable or too costly in developing regions, so there must be community-wide efforts to eradicate causes of AKI, expedite diagnosis, and aggressively manage prerenal conditions and specific infections. We have reviewed recent literature on AKI, identified differences and similarities in the condition between developed and developing areas, analyzed the practical implications of the identified differences, and made evidence-based recommendations for study and management. |
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Authors:
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Jorge Cerdá; Arvind Bagga; Vijay Kher; Rajasekara M Chakravarthi |
Publication Detail:
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Type: Comparative Study; Journal Article; Review Date: 2008-01-15 |
Journal Detail:
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Title: Nature clinical practice. Nephrology Volume: 4 ISSN: 1745-8331 ISO Abbreviation: - Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-27 Completed Date: 2008-07-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101261800 Medline TA: Nat Clin Pract Nephrol Country: England |
Other Details:
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Languages: eng Pagination: 138-53 Citation Subset: IM |
Affiliation:
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Division of Nephrology, Albany Medical College, Albany, NY 12209, USA. cerda@nycap.rr.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Developed Countries* Developing Countries* Humans Incidence Kidney Failure, Acute / epidemiology*, etiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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