Document Detail

The contraction fraction (CF) in myocardial studies with technetium-99m-isonitrile (MIBI)--correlations with radionuclide ventriculography and infarct size measured by SPECT.
MedLine Citation:
PMID:  2806328     Owner:  NLM     Status:  MEDLINE    
Criteria for the detection of coronary artery disease in nuclear cardiology include visualization of perfusion defects and functional impairment of contraction. The purpose of this study is to combine both methods in one procedure with the new myocardial perfusion tracer, 99mTc-methoxy-isobutyl-isonitril (MIBI), reducing time and radiation burden to the patient. Following an uncomplicated recovery, ten patients with first myocardial infarction participated in this study. Radionuclide ventriculography (RNV) was performed at rest and during exercise. Within 2-3 days, 370 MBq 99mTc-MIBI were injected and SPECT acquisition commenced 1 h later. Data processing included a scar image in polar coordinates. Areas of significantly reduced tracer uptake were expressed as a percentage of the total myocardial area. Directly following SPECT, resting and maximum exercise gated planar LAO images were recorded and the contraction was quantified. The concept of the contraction fraction (CF) rested on the end systolic change in count distribution: their increase in density and their centripetal concentration. For comparison, geometrical inner edge detection techniques were also applied. All algorithms for describing an EF equivalent were verified by computer simulations, showing a perfect correlation over a wide range of preset EFs. When applied to the patient studies only the non geometric methods revealed a good correlation with the ejection fraction (EF) obtained by RNV, and with the infarct size measured by SPECT.(ABSTRACT TRUNCATED AT 250 WORDS)
M Clausen; E Henze; A Schmidt; R Weller; R Lietzenmayer; D Hellwig; F Bitter; P Hildebrand; V Hombach; W E Adam
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of nuclear medicine     Volume:  15     ISSN:  0340-6997     ISO Abbreviation:  Eur J Nucl Med     Publication Date:  1989  
Date Detail:
Created Date:  1989-12-07     Completed Date:  1989-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7606882     Medline TA:  Eur J Nucl Med     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  661-4     Citation Subset:  IM    
Department of Nuclear Medicine, University Medical School, Ulm, Federal Republic of Germany.
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MeSH Terms
Myocardial Contraction*
Myocardial Infarction / physiopathology,  radionuclide imaging*
Organotechnetium Compounds
Radionuclide Ventriculography
Technetium Tc 99m Sestamibi
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
0/Nitriles; 0/Organotechnetium Compounds; 109581-73-9/Technetium Tc 99m Sestamibi

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